John L. Mignone, MD, PhD

Accepting New Patients
Offers Video Visits
1600 East Jefferson Street, Suite 600
Seattle, WA 98122
2296.7 miles away
Medical Groups & Affiliations
Speaks: English

John L. Locke Jr. Advanced Cardiac Support Program

1600 East Jefferson Street, Suite 600, Seattle, WA 98122

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About John L. Mignone

In the Advanced Cardiac Support clinic, patients will receive the comprehensive care needed for heart failure treatment. Dr. Mignone and his team have created a comprehensive approach to managing heart failure allowing patients a level of support unique to managing this disease. They aim to be the patient's partner and work together to make a treatment plan that best suits the needs and objectives of each individual patient.


University of Washington
Internal Medicine

Medical School

Duke University



University of Washington
Advanced Heart Failure and Transplant Cardiology

Professional Associations
John L. Locke Jr. Advanced Cardiac Support Program
1600 East Jefferson Street, Suite 600
Seattle, WA 98122

Swedish Heart & Vascular - Issaquah
751 Northeast Blakely Drive, Suite 3020
Issaquah, WA 98029

Medical Groups & Affiliations

Affiliated Locations
Swedish Issaquah
Swedish Cherry Hill
Swedish First Hill

Dr. Mignone is personally interested in genetic cardiomyopathies, cardiac amyloidosis and advanced heart failure management with ventricular assist devices. He has a strong interest in research, and currently, the heart failure clinic is enrolling in over 10 heart failure related clinical trials. The Advanced Cardiac Support program also has the longest practice knowledge in the Pacific Northwest using the cardiomem device for managing very complicated heart failure patients, particularly those people far from Seattle to help keep close management of the disease from the comfort of their own homes.

Clinical Interests

  • Advanced Heart Failure (Adhf)
  • Cardiac Amyloid
  • Cardiac Arrest
  • Cardiac Catheterization
  • Cardiac Disease In Pregnancy
  • Cardiac Sarcoidosis
  • Cardiomyopathy
  • Centrimag Ventricular Assist Device Surgery
  • Congestive Heart Failure (Chf)
  • Extracorporeal Membrane Oxygenation
  • Familial Dilated Cardiomyopathy
  • Familial Hypertrophic Cardiomyopathy
  • Family History Of Sudden Cardiac Death
  • Heart Transplant
  • Hypertrophic Cardiomyopathy
  • Infiltrative Disorders Of The Heart
  • Intra Aortic Balloon Pump
  • Mechanical Circulatory Support
  • Myocarditis
  • Transplant Medicine
  • Ventricular Assist Device Bridge To Recovery
  • Ventricular Assist Device Bridge To Transplant
  • Ventricular Assist Device For Destination Therapy
  • Virtual Care