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Photo of Thomas Ken Takayama

Thomas K. Takayama, MD

Languages: English, Japanese
Accepting New Patients
Field of Study
Tufts University School of Medicine
Medical School
University of Washington
Dept of Urology
University of Washington
Urologic Oncology
Professional Associations
American Urological Association, Washington State Medical Association
Personal Interests
Family, Fishing, Skiing
Board Certifications
  • American Board of Urology, Urology
Clinical Interests
  • asymptomatic bacturia
  • atony urinary bladder
  • balanitis
  • balanoposthitis
  • benign prostatic hypertrophy
  • biopsy of penis
  • biopsy of periurethral tissue
  • biopsy of scrotum or tunica vaginalis
  • biopsy of urethra
  • bladder disease
  • bladder diverticulum
  • bladder exstrophy
  • bladder fistula
  • bladder hemorrhage
  • bladder neck obstruction
  • bladder sphincterotomy
  • bladder trauma
  • bph surgery
  • catheter
  • circumcision
  • condylomata acuminata
  • congenital anomaly of urinary system
  • continuous leakage of urine
  • crushing injury of external genitalia
  • cystectomy
  • cystogram
  • cystometry
  • cystoscopy
  • cystoureterostomy
  • cystourethroscopy
  • cystourethrostomy
  • detrusor instability
  • dilatation of ureter
  • dilation of ureteral meatus
  • dysplasia of prostate
  • ectopic ureter
  • edema of male genital organs
  • edema of penis
  • elevated psa
  • encysted hydrocele
  • enlarged prostate
  • enterovesical fistula
  • epididymal cyst removal
  • epididymal mass
  • epididymectomy
  • epididymitis
  • epididymo-orchitis
  • epididymotomy
  • epispadias
  • female genital problems
  • foreign body in genitourinary tract
  • foreign body in penis
  • frenulotomy of penis
  • frequency of urination
  • frequent urinary tract infections
  • frostbite of penis
  • functional incontinence
  • genital herpes, female
  • genital herpes, male
  • granuloma inguinale
  • groin mass
  • hematuria
  • hydrocele
  • hydrocelectomy
  • hypoplasia of penis
  • hypospadias
  • ileal conduit
  • increased frequency of micturition
  • infected hydrocele
  • infection of cystostomy
  • infection of kidney
  • insertion of testicular prosthesis
  • interstim
  • interstitial cystitis
  • intra-lesional therapy for peyronie's disease
  • kidney injury
  • kidney malformation
  • kidney stone
  • laparoscopic urology
  • lichen sclerosus of penis
  • lysis of penile adhesions
  • male genital organ stricture
  • male genital problems
  • meatal stenosis
  • micropenis
  • microscopic hematuria
  • mixed incontinence
  • nephrectomy
  • nephropexy
  • nephrostomy
  • nephrotomy
  • nephroureterectomy
  • neurogenic urinary bladder
  • nocturia
  • nontraumatic rupture of bladder
  • open pyeloplasty
  • overactive bladder
  • overflow incontinence of urine
  • painful bladder syndrome
  • paralysis of bladder
  • partial cystectomy
  • partial nephrectomy
  • partial orchiectomy
  • penile bleeding
  • penile chordee
  • penile discharge
  • penile fibrosis
  • penile hypoplasia
  • penile hypospadias
  • penile induration
  • penile leukoplakia
  • penile plaque
  • penile prosthesis
  • penis
  • penis straightening chordee
  • periurethral abscess
  • peyronie's
  • phimosis
  • plastic urethral sphincter
  • polyuria
  • post prostatectomy erectile impairment
  • post-prostatectomy incontinence
  • post-void dribbling
  • post-void residual
  • prostate abscess
  • prostate bleeding
  • prostate examination
  • prostate infection
  • prostate specific antigen
  • prostatic atrophy
  • prostatic cyst
  • prostatic hyperplasia
  • prostatic hypertrophy
  • prostatic massage
  • prostatitis
  • pyelitis
  • pyelonephritis
  • pyeloscopy
  • pyelostomy
  • radiation cystitis
  • radioactive seed implants
  • reconstruction of urethra
  • rectourethral fistua
  • recurrent urinary tract infection
  • release of chordee
  • removal of internal penile prosthesis
  • renal cortical necrosis
  • renal denervation
  • renal disease and pregnancy
  • repair of rectourethral fistula
  • replacement of ureterostomy tube
  • reversal of vasectomy
  • screening for malignant neoplasms of prostate
  • screening for malignant neoplasms of testis
  • scrotal abscess
  • scrotal cyst
  • scrotal disorder
  • scrotal mass
  • scrotal pain
  • scrotectomy
  • semen abnormality
  • sexually transmitted diseases
  • slowing of urinary stream
  • spermatic cord torsion
  • spermatocele
  • spermatocele aspiration
  • straining on urination
  • stress incontinence
  • stretching of prepuce
  • swollen penis
  • testicular atrophy
  • testicular hydrocele
  • testicular pain
  • testopel treatment
  • total incontinence
  • transgender surgery
  • transurethral balloon dilation of prostatic urethra
  • transurethral cystoscopy
  • transurethral prostatectomy
  • unilateral orchidectomy
  • ureter
  • ureteral meatotomy
  • ureteral stent
  • ureterectomy
  • ureteric fistula
  • ureteric obstruction
  • ureterocele
  • ureteroenterostomy
  • ureterolithotomy
  • ureteropelvic junction obstruction
  • ureteroplasty
  • ureterotomy
  • urethra
  • urethral abscess
  • urethral caruncle
  • urethral discharge
  • urethral diverticulum
  • urethral false passage
  • urethral fistula
  • urethral polyps
  • urethral stenosis
  • urethral stricture
  • urethral syndrome
  • urethrocystopexy
  • urethromeatoplasty
  • urethropexy
  • urethrotomy
  • urinary diversion
  • urinary hesitation
  • urinary retention
  • urinary tract infection
  • urinary tract injury
  • urinary tract malformation
  • urinary tract obstruction
  • urinary urgency
  • urine
  • uroflowmetry
  • varicocele
  • vasectomy
  • vesicocutaneous fistula
  • vesicoureteral reflux
  • video urodynamic
  • voiding dysfunction

1. Miller-Graziano, C., Szabo, G., Takayama, T.K., Interleukin-4 Effects on Monocyte Prostaglandin E2 and Tumor Necrosis Factor. J. Leukocyte Biol. 44, 273 (1988)

2. Miller-Graziano, C., Szabo, G., Takayama, T.K., Wu, J, Alterations of monocyte function following major surgery. In (Faist, E., Ed.) The Immune Consequences of Trauma, Shock and Sepsis. Springer-Verlag, pp.95-109.(1989)

3. Zappala, S., Khauli, R., Miller-Graziano, C., Stoff, J., Takayama, T.K., Menon, M., Evaluation of Monocyte Procoagulant Activity as a Parameter for Immunological Monitoring in Renal Transplantation. Transplant Proc. 21, 1844-1855 (1989)

4. Szabo, G., Miller-Graziano, C., Wu, J., Takayama, T.K., Kodys, K., Differential Tumor Necrosis Factor Production by Human Monocyte Subsets. J. Leukocyte Biol. 47, 206-216 (1990)

5. Takayama, T.K., Miller-Graziano, C., Szabo, G., Elevated Tumor Necrosis Factor Production Concomitant to Elevated Prostaglandin E2 Production by Trauma Patients' Monocytes. Arch. Surg. 125, 29-35 (1990)

6. Riley, D.E., Roberts, M.C., Takayama, T.K., Krieger, J.N., Development of a Polymerase Chain Reaction-Based Diagnosis of Trichimonas Vaginalis. J. Clin. Microbiol. 30, 465-472 (1992)

7. Takayama, T.K., Krieger, J.N., True, L.D., Lange, P.H., Recurrent Prostate Cancer Despite Undetectable Prostate Specific Antigen. J. Urol. 148, 1541-1542 (1992)

8. Takayama, T.K., and Brawer, M.K., Prostate Ultrasonography, Normal and Benign Conditions. World J. Urology. 10(4):198-202 (1992)

9. Takayama, T.K., Vessella, R.L., Brawer, M.K., Noteboom,J., and Lange, P.H., The enhanced detection of persistent disease after radical prostatectomy with a new prostate specific antigen (PSA) immunoassay. J. Urol. 150(2): 374-378 (1993)

10. Takayama, T.K., Vessella, R.L., and Lange, P.H., A brief review of ultrasensitive prostate-specific antigen assays for the evaluation of patients after radical prostatectomy. World J. Urology. 11(4):192-195 (1993)

11. Takayama, T.K., Vessella, R.L., Brawer, M.K., Noteboom,J., and Lange, P.H., Urinary prostate specific antigen levels after radical prostatectomy. J. Urol. 151(1):82-87. (1994)

12. Takayama, T.K., Vessella, R.L., and Lange, P.H., Newer Applications of serum prostate specific antigen in the management of prostate cancer. Seminars in Oncology, 21(5):542-553 (1994)

13. Takayama, T.K. and Lange, P.H., Radiation therapy for local recurrence of prostate cancer after radical prostatectomy. Urol. Clin. N. Amer., 21(4):687-700 (1994)

14. Takayama, T.K. and Lange, P.H., Prostate carcinoma (counterpoint) in Cancer Patient Follow-up, Johnson, F.E and Virgo, K.S., eds., Mosby-Year Book, Inc., pp.400-405 (1997)

15. Porter, J.R. Takayama, T.K. and Defalco, A.J. Traumatic posterior urethral injury and early realignment using magnetic urethral catheters. J Urol. 158(2):425-30 (1997)

16. Takayama, T.K., Fujikawa, K. and Davie, E.W., Characterization of the precursor of prostate specific antigen: activation by trypsin and human glandular kallikrein. J. Biol. Chem. 272(34):21582-21588 (1997)

17. Takayama, T.K., Carter, C.A. and Deng, T. Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR. Biochemistry, 40(6): 1679-1687 (2001)

18. Cooley, J., Takayama, T.K., Schechter, N.M. and Remold-O’Donnell, E. The serpin MNEI inhibits elastase-like chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry, 40(51): 15762-70 (2001)

19. Zheng, X., Chung, D., Takayama, T.K., Majerus, E.M., Sadler, J.E. and Fujikawa, K. Structure of von Willebrand factor cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J. Biol. Chem., 276(44): 41059-63 (2001)

20. Takayama, T.K., McMullen, B.A., Nelson, P.S., Matsumura, M. and Fujikawa, K. Characterization of hK4 (prostase), a prostate specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase. Biochemistry, 40(50): 15341-8 (2001)

21. Greenberg, D.L., Mize, G.J., and Takayama, T.K. Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells. Biochemistry, 42(3): 702-9 (2003)

22. Black PC, Lange PH, Takayama, T.K. Extensive palliative surgery for advanced mesothelioma of the tunica vaginalis. Urology, 62(4): 748 (2003)

23. Matsumura, M., Bhatt, A.S., Andress, D., Clegg, N., Takayama, T.K., Craik, C.S., Nelson, P.S. Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries. Prostate. 62(1):1-13 (2005).

24. Cuevas C, Raske M, Bush WH, Takayama T, Maki JH, Kolokythas O, Meshberg E. Imaging primary and secondary tumor thrombus of the inferior vena cava: multi-detector computed tomography and magnetic resonance imaging. Curr Probl Diagn Radiol. May-Jun;35(3):90-101 (2006) May.

25. Sim HG, Kliot M, Lange PH, Ellis WJ, Takayama TK, Yang CC. Two-year outcome of unilateral sural nerve interposition graft after radical prostatectomy. Urology. Dec;68(6):1290-4 (2006) Dec.

26. Dighe M, Takayama T, Bush WH Jr. Preoperative planning for renal cell carcinoma--benefits of 64-slice CT imaging. Int Braz J Urol. 33(3):305-12 (2007) May.

27. Black, PC, Mize, GJ, Karlin, P, Greenberg, DL, Hawley, SJ, True, LD, Vessella, RL, and Takayama, TK. Over-expression of Protease-Activated Receptors-1,-2 and-4 (PAR-1, -2, and -4) in prostate cancer. The Prostate 67(7):743-56 (2007) May.

28. Kenerson1 H, Folpe A, Takayama TK, Yeung RS. Activation of the mTOR pathway in sporadic angiomyolipomas and PEComas. Human Pathology 38(9):1361-71 (2007) Sep.

29. Mize GJ, Wang W, Takayama TK. Prostate-Specific Kallikreins-2 and -4 Enhance the Proliferation of DU-145 Prostate Cancer Cells through Protease-Activated Receptors-1 and -2. Mol Cancer Res. 6(6):1043-51 (2008) Jun.

30. Wang W, Zhang X, Mize GJ, Takayama TK. Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. The Prostate. 68(10):1064-75 (2008) Jul.

31. Mize GJ, Harris JE, Takayama TK, Kulman JD. Regulated expression of active biotinylated G-protein coupled receptors in mammalian cells. Protein Expr Purif. 57(2):280-9 (2008) Feb.

32. Wang W, Zhang X, Mize GJ, Takayama TK. Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. Prostate. 2008 Jul 1;68(10):1064-75.

33. Mize GJ, Wang W, Takayama TK. Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2. Mol Cancer Res. 2008 Jun;6(6):1043-51.

34. Zhang X, Wang W, True LD, Vessella RL, Takayama TK. Protease-activated receptor-1 is upregulated in reactive stroma of primary prostate cancer and bone metastasis. Prostate. 2009 May 15;69(7):727-36.

35. Swedberg JE, Nigon LV, Reid JC, de Veer SJ, Walpole CM, Stephens CR, Walsh TP, Takayama TK, Hooper JD, Clements JA, Buckle AM, Harris JM. Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4. Chem Biol. 2009 Jun 26;16(6):633-43.

36. Pascal LE, Goo YA, V�ncio RZ, Page LS, Chambers AA, Liebeskind ES, Takayama TK, True LD, Liu AY. Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes. BMC Cancer. 2009 Sep 8;9:317.

37. Wang W, Mize GJ, Zhang X, and Takayama TK. Kallikrein-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1. International Journal of Cancer. 2010 Feb 1;126(3):599-610.

Washington Urology & Urogynecology
1135 116th Avenue Northeast Suite 620
Bellevue, WA 98004
Affiliated Facilities
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