Photo of Kris V. Kowdley

Kris V. Kowdley, M.D.


Professional Statement

Kris V. Kowdley MD, FACP, FACG, AGAF, FAASLD is Director of the Liver Care Network, and Organ Care Research at Swedish Medical Center located in Seattle, Washington. Dr. Kowdley received his BS in Biology and Anthropology as a member of the Dean's List at Columbia University, and his medical degree from Mount Sinai School of Medicine. He completed his internship and residency at Oregon Health Science University and a Fellowship in Gastroenterology and Hepatology at Tufts University School of Medicine. Dr. Kowdley is recognized as a world-renowned leader in the field of hepatology, and has presented his research on liver diseases at more than 135 national and international meetings and scientific symposia. He is the author of over 375 articles, book chapters, reviews and commentaries in professional publications. Dr. Kowdley also maintains an active practice in hepatology and has interests and expertise in specialized genetic liver diseases, fatty liver disease, viral hepatitis, and cholestatic liver diseases.

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Mount Sinai School of Medicine
medical school, 1985
Internal Medicine, Oregon Health Sciences University, Portland, OR
Gastroenterology & Hepatology, Tufts University School of Medicine, Boston, MA

Board Certifications

American Board of Internal Medicine
American Board of Internal Medicine
Internal Medicine

Clinical Interests

  • Abdominal Pain
  • Abnormal Amylase
  • Abnormal Bowel Movement
  • Abnormal Liver Function
  • Abnormal Stool
  • Achalasia
  • Acholic Stools
  • Acute Pancreatitis
  • Alagille Syndrome
  • Alcoholic Cirrhosis
  • Alcoholic Encephalopathy
  • Alcoholic Hepatitis
  • Allergic Colitis
  • Allergic Esophagitis
  • Allergic Gastroenteritis
  • Alpha 1 Antitrypsin Deficiency
  • Altered Bowel Habits
  • Anal Fissure
  • Anal Fistula
  • Anal Pain
  • Anal Polyp
  • Anal Spasm
  • Anal Stenosis
  • Anal Ulcer
  • Anorectal Disease
  • Anorexia
  • Appetite Loss
  • Ascites
  • Autoimmune Enteropathy
  • Autoimmune Hepatitis
  • Barretts Esophagus
  • Bile Duct Cancer
  • Biliary Atresia
  • Biliary Cirrhosis
  • Biologic Therapy For Gastrointestinal Diseases
  • Bleeding Hemorrhoids
  • Blood In Stool
  • Bright Red Blood Per Rectum
  • Budd Chiari Syndrome
  • Celiac Disease
  • Choking Sensation
  • Cholangitis
  • Cholecystitis
  • Cholelithiasis
  • Cholestasis
  • Chronic Diarrhea
  • Chronic Pancreatitis
  • Cirrhosis
  • Clostridium Difficile
  • Colic
  • Colitis
  • Colonic Polyps
  • Colonoscopy
  • Congenital Cystic Of Liver
  • Congenital Hepatic Fibrosis
  • Constipation
  • Crigler Najjar Syndrome
  • Cyclic Vomiting Syndrome
  • Cystic Fibrosis - Gi Complications
  • Diarrhea
  • Diverticular Disease
  • Diverticulitis
  • Diverticulosis
  • Duodenal Ulcer
  • Duodenitis
  • Dysphagia
  • Elevated Amylase
  • End Stage Liver Disease
  • Endoscopy
  • Eosinophilic Esophagitis
  • Eructation
  • Esophageal Disorder
  • Esophageal Mass
  • Esophageal Ulcer
  • Esophageal Varices
  • Esophagitis
  • Fatty Liver
  • Fecal Impaction
  • Fecal Incontinence
  • Feeding Problems
  • Fibrocystic Liver
  • Flatulence
  • Gallbladder Disease
  • Gallbladder Polyp
  • Gastric Anomaly
  • Gastric Ulcer
  • Gastritis
  • Gastroesophageal Reflux Disease
  • Gastrointestinal Bleeding
  • Gastroparesis
  • Giardiasis
  • Gluten Sensitivity
  • Glycogen Storage Disease
  • Graft Versus Host Disease
  • Helicobacter Pylori
  • Helminthiasis
  • Hematemesis
  • Hematochezia
  • Hemochromatosis
  • Hemorrhoids
  • Hemorrhoids With Complications
  • Hepatic Encephalopathy
  • Hepatic Hydrothorax
  • Hepatitis
  • Hepatitis B
  • Hepatitis C
  • Hepatitis D
  • Hepatoblastoma
  • Hepatorenal Syndrome
  • Hereditary Nonpolyposis Colorectal Cancer
  • Hiatal Hernia
  • Hirschsprungs Disease
  • Hydrops Of Gallbladder
  • Hyperbilirubinemia
  • Hyperoxaluria
  • Icterus
  • Idiopathic Megacolon
  • Ileitis
  • Ileoscopy
  • Inflammatory Bowel Disease
  • Interferon
  • Intestinal Atresia
  • Intestinal Obstruction
  • Intestinal Pseudo-Obstruction
  • Intractable Vomiting
  • Intussusception
  • Irritable Bowel Syndrome
  • Jaundice
  • Lactose Intolerance
  • Liver Biopsy
  • Liver Disease
  • Liver Failure
  • Liver Hemangioma
  • Liver Mass
  • Liver Transplant
  • Malabsorption
  • Malignant Neoplasm Of Liver
  • Malnutrition
  • Meckel's Diverticulum
  • Megacolon
  • Megarectum
  • Melena
  • Metabolic Abnormality
  • Metabolic Liver Disease
  • Nausea
  • Obstipation
  • Odynophagia
  • Pancreatic Insufficiency
  • Pancreatitis
  • Peptic Ulcer
  • Peritonitis
  • Polyposis Syndrome
  • Polyps
  • Portal Hypertension
  • Portal Hypertensive Gastropathy
  • Portal Pyemia
  • Portal Vein Thrombosis
  • Primary Biliary Cirrhosis
  • Proctosigmoidoscopy
  • Pseudocyst
  • Rectal Bleeding
  • Rectal Fistula
  • Rectal Hemorrhage
  • Rectal Pain
  • Rectal Polyp
  • Regional Enteritis
  • Right Lower Quadrant Pain
  • Right Upper Quadrant Pain
  • Sclerosing Cholangitis
  • Short Bowel Syndrome
  • Small Bowel Disease
  • Stomach Cancer
  • Stomach Cramps
  • Stomach Pain
  • Swallowing Problem
  • Tenesmus
  • Tyrosinemia
  • Ulcerative Colitis
  • Vomiting
  • Whipple Disease
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Personal Interests

Cycling, Wine Collecting
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Kowdley KV, Lawitz E, Crespo I, Hassanein T, Davis MN, Demicco M, Bernstein DE, Afdhal N, Vierling JM, Gordon SC, Anderson JK, Hyland RH, Dvory-Sobol H, An D, Hindes RG, Albanis E, Symonds WT, Berrey MM, Nelson DR, Jacobson IM. Sofosbuvir with pegylated interferon alfa-2a and ribavirin for treatment-naïve patients with hepatitis C genotype-1 infection (ATOMIC): an open-label, randomised, multicentre phase 2 trial. Lancet. 2013 Jun 15;381(9883):2100-7. 

Kanwar P, Kowdley KV. Metal storage disorders: Wilson disease and hemochromatosis. Med Clin North Am. 2014 Jan;98(1):87-102.

Kowdley KV, Lawitz E, Poordad F, Cohen DE, Nelson DR, Zeuzem S, Everson GT, Kwo P, Foster GR, Sulkowski MS, Xie W, Pilot-Matias T, Liossis G, Larsen L, Khatri A, Podsadecki T, Bernstein B. Phase 2b trial of interferon-free therapy for hepatitis C virus genotype 1. N Engl J Med. 2014 Jan 16;370(3):222-32.

Kowdley KV. Advances in the diagnosis and treatment of nonalcoholic steatohepatitis. Gastroenterol Hepatol (N Y). 2014 Mar;10(3):184-6.

Kowdley KV, Gordon SC, Reddy KR, Rossaro L, Bernstein DE, Lawitz E, Shiffman ML, Schiff E, Ghalib R, Ryan M, Rustgi V, Chojkier M, Herring R, Di Bisceglie AM, Pockros PJ, Subramanian GM, An D, Svarovskaia E, Hyland RH, Pang PS, Symonds WT,  McHutchison JG, Muir AJ, Pound D, Fried MW; the ION-3 Investigators. Ledipasvir and Sofosbuvir for 8 or 12 Weeks for Chronic HCV without Cirrhosis. N Engl J Med. 2014 May 15;370(20):1879-88. 

Minaei AA, Kowdley KV. ABT-450/ ritonavir and ABT-267 in combination with ABT-333 for the treatment of hepatitis C virus. Expert Opin Pharmacother. 2015 Apr;16(6):929-3.

Lindor KD, Kowdley KV, Harrison ME. ACG Clinical Guideline: Primary Sclerosing Cholangitis. Am J Gastroenterol. 2015 May;110(5):646-59.

Kowdley KV, An D, Pang PS, Wyles D. Analysis of subgroup differences in the ION-3 trial of ledipasvir-sofosbuvir in chronic hepatitis C infection. Open Forum Infectious Diseases. 2015 2(2):ofv056.

Ness E, Kowdley KV. Update on Hepatitis C: epidemiology, treatment and resistance to antiviral therapies. Minerva Gastroenterol Dietol. 2015 Sep;61(3):145-58.

Find a complete list of Dr. Kowdley’s publications.

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Professional Associations

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  • English
  • Tamil

Practice Locations

Kris V. Kowdley practices at one location

Swedish Organ Transplant and Liver Center
1124 Columbia Street
Suite 600
Seattle, WA 98104
Affiliated Facilities
  • Swedish Cherry Hill
  • Swedish First Hill
Medical Groups
Swedish Medical Group logo