Photo of John L. Mignone

John L. Mignone, M.D., Ph.D.

Robert M. and Patricia Arnold Endowed Medical Director for Heart Failure

Cardiology, Heart Failure and Transplantation Cardiology

Accepting New Patients


Professional Statement

In our clinic, you will receive the comprehensive care that a patient with heart failure requires. We have created a comprehnesive approach to managing heart failure allowing a patient a level of support unique to managing this disease. We aim to be your partner as we work together to make a treatment plan that best suits your needs and objectives.

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Duke University
medical school, 2006
University of Washington
residency, Internal Medicine, 2008
University of Washington
fellowship, Advanced Heart Failure and Transplant Cardiology, 2014

Board Certifications

American Board of Internal Medicine
Advanced Heart Failure and Transplant Cardiology
American Board of Internal Medicine
Cardiovascular Disease
American Board of Internal Medicine
Internal Medicine

Clinical Interests

  • Advanced Heart Failure
  • Cardiac Amyloid
  • Cardiac Arrest
  • Cardiac Catheterization
  • Cardiac Disease In Pregnancy
  • Cardiac Sarcoidosis
  • Cardiomyopathy
  • Centrimag Ventricular Assist Device
  • Congestive Heart Failure
  • Extracorporeal Membrane Oxygenation
  • Heart Transplant
  • Hypertrophic Cardiomyopathy
  • Infiltrative Disorders Of The Heart
  • Intra-Aortic Balloon Pump
  • Mechanical Circulatory Support
  • Myocarditis
  • Sudden Cardiac Death
  • Transplantation Medicine
  • Ventricular Assist Device Bridge-To-Recovery
  • Ventricular Assist Device Bridge-To-Transplant
  • Ventricular Assist Device For Destination Therapy
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Personal Interests

I am personally interested in genetic cardiomyopathies, cardiac amyloidosis and advanced heart failure management with ventricular assist devices. I have a strong interest in research, and currently, the heart failure clinic is enrolling in over 10 heart failure related clinical trials. We also have the longest practice knowledge in the Pacific Northwest using the cardiomem device for managing very complicated heart failure patients, particularly those people far from Seattle to help keep close management of the disease from the comfort of your own home.
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Professional Associations

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  • English

Practice Locations

John L. Mignone practices at two locations

John L. Locke Jr. Advanced Cardiac Support Program
1600 East Jefferson Street
Suite 600
Seattle, WA 98122
Swedish Heart & Vascular - Issaquah
751 Northeast Blakely Drive
Suite 3020
Issaquah, WA 98029
Affiliated Facilities
  • Swedish Cherry Hill
  • Swedish First Hill
  • Swedish Issaquah
Medical Groups
Swedish Medical Group logo