As many as 100,000 Americans suffer from a disorder called pseudotumor cerebri or idiopathic intracranial hypertension that can cause permanent blindness and chronic headaches. The disease primarily strikes obese women of reproductive age with symptoms of daily headaches, visual symptoms including transient blurring or blindness, double vision, and pulsating noises in one’s head. Up to 5-10% of these patients may have permanent visual loss due to optic nerve damage.
A recent national trial funded by the National Institute of Health’s National Eye Institute has shown that a common water pill, acetazolamide, combined with a moderate but comprehensive dietary and lifestyle modification plan can restore and preserve vision in women with this disease. I was one of the local investigators for this trial along with Dr. Eugene May.
Principal investigator for multiple clinical trials on MS research and other projects involving optic nerve diseases
Hamilton SR, Chatrian GE, Mills RP, Kalina RE, Bird, TD. Cone dysfunction in a subgroup of patients with autosomal dominant cerebellar ataxia. Arch Ophthalmol. 1990; 108: 551-556.
Hamilton SR, Lessell S. Recurrent idiopathic lateral rectus muscle palsy in adults. American Journal of Ophthalmology 1991; 112: 540-542.
Hamilton SR, Smith, CH, Lessell S. Idiopathic hypertropic cranial pachymenigitis. Journal of Clinical Neuro-Ophthalmology 1993; 13 (2): 127-134.
Farrell DF, Hamilton, SR, Knauss TM, et al. X-linked adrenoleukodystrophy (ALD): Adult cerebral variant. Neurology 1993;43: 1518-1522.
Myers, MA, Hamilton, SR, Begosian AJ, Smith CH, Wagner TA. Visual loss as a complication of spine surgery. Spine 1997; 22: 1325-1329.
Hamilton SR. Neuro-ophthalmology of Eye Movement Disorders. Current Opinion in Ophthalmology 1999;10: 405-410.
Hamilton SR. Neuro-ophthalmology of Movement Disorders. Current Opinion in Ophthalmology 2000;11.
Hamilton SR. Myasthenia Gravis and Ocular Myopathies, in Neuro-Ophthalmology: The Practical Guide, edited by Levin, LA, and Arnold, AC., 2005.
Hamilton, SR. Sarcoidosis, in Walsh and Hoyt’s Clinical Neuro-ophthalmology, edited by Miller, NR, Newman, NJ, Biousse, V, and Kerrison, JB, sixth edition, 2005.
Rucker JS, Hamilton SR, Bardenstein D, Isada CM, Lee MS.Linezolid-associated Toxic Optic Neuropathy. Neurology 2006,28:595-8.
Newman NJ, Biousee V, Newman SA, Bhatti MT, Hamilton SR, Farris BK, Lesser RL, Turbin RE. Progression of Visual Field Defects in Leber Hereditary Optic Neuropathy: Experience of the LHON Treatment Trial. Am J Ophthalmol 2006;141:1061-1067.
Optic Neuritis Study Group. Visual Function 15 Years after Optic Neuritis: A Final Follow up Report from the Optic Neuritis Treatment Trial. Ophthalmology 2008;115:1079-1082.
Optic Neuritis Study Group. Multiple Sclerosis Risk after Optic Neuritis: Final Optic Neuritis Treatment Trial Follow Up. Arch Neurology 2008;65:727-732.
Hamilton SR, Lam D, Miller NR. Myasthenia, in Albert and Jakobiec’s Principles and Practice of Ophthalmology, edited by Albert, DM, Miller JW, Azar, DT, and Blodi BA, 3rd edition, 2008.
Hamilton SR. What is the Appropriate Evaluation in a Patient Suspected of Having a Sixth Nerve Palsy?, in Curbside Consultation in Neuro-ophthalmology: 49 Clinical Questions, edited by Andrew G. Lee, in press.Zuchner S, De Jonghe P, Jordanova A et al. Axonal neuropathy with optic atrophy is caused by mutations in mitofusin 2. Ann Neurol 2006;59(2):276-81.