Swedish Research Study
Swedish Medical Center is conducting the REACT COVID-19: Real world Evidence for Anti-Cytokine Therapy in COVID-19, an international, multi-center, observational study.
Background: The clinical question of whether anti-cytokines, like tocilizumab, may help treat or prevent progression of severe manifestations of COVID-19 such as lung injury, ARDS, shock, organ dysfunction, or death is of critical importance. Data from China and Italy, indicate that hospitalized COVID-19 patients have high rates of ICU admissions namely due to rapidly progressive respiratory failure. This appears to be the leading cause of death in these patients and occurs in patients of all age groups. Our own emerging clinical experiences in Seattle, parallels that.
Initial work from China suggests that these patients have clinical syndromes and biochemical cytokine profiles similar to what we see in Cytokine Release Syndrome (CRS) due to Immune Effector cell therapies for lymphoid malignancies such as CART cell therapy or bispecific antibodies. As such, there are global RCTs in the works to assess use of anti-cytokines like tocilizumab in such COVID-19 patients.
However, many of us are seeing these very ill patients right now or will be soon and not all will have access to the trials and many patients may be ineligible for the studies. There is quickly growing use of "off label" anti-cytokines to try to help these patients. We believe it is critically important for us as a research community to systematically capture pertinent clinical data about outcomes in patients treated with "off label" tocilizumab and other anti-cytokine therapies rapidly, so that we can rapidly try to bridge knowledge gaps until data is available from the larger RCTs and ask for your participation in this global registry.
In this data capture study, we are not advocating for or recommending that you use anti-cytokine therapies for these patients, but rather asking that if your institution has decided to do so or is already doing so, please join our international effort to rapidly learn about what happens in such patients. Information on how to contact is listed below. These efforts may help save lives.
-The React Team