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A Clinical Evaluation of the Safety and Effectiveness of the MitraClip® System for the Treatment of Functional Mitral Regurgitation in Symptomatic Subjects who are Extremely High Risk for Mitral Valve Surgery - COAPT

To evaluate the safety and effectiveness of the MitraClip System for the treatment of moderate-to-severe or severe functional mitral regurgitation...

John Petersen II, MD

A Pivotal Trial to Establish Efficacy and Long-Term Safety of the Parachute Implant System

To evaluate the reasonable assurance of safety and effectiveness of the CKI Parachute implant in the treatment of patients with NYHA Class III or...

Paul Huang, MD

A Study to Evaluate the Safety and Feasibility of Transcranial MRI-Guided Focused Ultrasound Surgery in the Treatment of Brain Tumors.

The purpose of this study it to evaluate the safety of MRI-guided focused ultrasound thermal ablation of brain tumors performed through intact...

Stephen Monteith, MD

A Randomized Phase 3 Open Label Study of Nivolumab Versus Bevacizumab and Multiple Phase 1 Safety Cohorts of Nivolumab or Nivolumab in Combination With Ipilimumab Across Different Lines of Glioblastoma

The purpose of the study is to compare the efficacy and safety of nivolumab administered alone versus bevacizumab in patients diagnosed with...

Tara L. Benkers, MD

The Prospective Randomized On-X Valve Anticoagulation Clinical Trial (PROACT)

A longitudinal, randomized study comparing the On-X valve on low dose anticoagulation (test group) to concomitant control groups of On-X valves...

Glenn Barnhart, MD

Non-interventional Study for the Generation of Long Term Safety and Efficacy Data of Pasireotide s.c. in Patients With Cushing's Disease (Post-Authorization Safety Study)

This is a non-interventional, multinational, multi-center post-marketing study, to further document the safety and efficacy of pasireotide s.c....

Zachary N. Litvack, MD MCR FAANS

BEST-CLI: RANDOMIZED, MULTICENTER, CONTROLLED TRIAL TO COMPARE BEST ENDOVASCULAR VERSUS BEST SURGICAL THERAPY IN PATIENTS WITH CRITICAL LIMB ISCHEMIA

To compare and evaluate the effectiveness of best endovascular compared to best surgical revascularization in patients with Critical Limb Ischemia.

P. Gregory Hayes, MD

REPRISE III: REPOSITIONABLE PERCUTANEOUS REPLACEMENT OF STENOTIC AORTIC VALVE THROUGH IMPLANTATION OF LOTUS VALVE SYSTEM - RANDOMIZED CLINICAL TRIAL EVALUATION

To evaluate the safety and effectiveness of the Lotus Valve System for transcatheter aortic valve replacement (TAVR) in symptomatic subjects with...

Ming Zhang, MD, PhD

A PHASE 0/1 STUDY OF COMBINATION DRUG THERAPY FOR GLIOBLASTOMA BASED ON PERSONALIZED CANCER STEM CELL (CSC) HIGH-THROUGHPUT DRUG SCREENING

A study to determine the safety of CSC/ HTS-based combination drug therapy in subjects who have GBM that has recurred or progressed following prior...

Charles S. Cobbs, MD

A Multi-center, Randomized, Open-label, Phase IV Study to Investigate the Management of Pasireotide-induced Hyperglycemia With Incretin Based Therapy or Insulin in Adult Patients With Cushing's Disease or Acromegaly

The study aims to demonstrate that pasireotide-induced hyperglycemia can be effectively and safely managed in majority of patients, including those...

Kevin Yuen, MD
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