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A Phase 2/3 Multicenter, Open-label, 3-arm, 2-Stage Randomized Study of ASP2215 (Gilteritinib), Combination of ASP2215 Plus Azacitidine and Azacitidine Alone in the Treatment of Newly Diagnosed Acute Myeloid Leukemia With FLT3 Mutation in Patients Not Eligible for Intensive Induction Chemotherapy

The purpose of this study is to determine the efficacy superiority of ASP2215 and/or ASP2215 plus azacitidine versus azacitidine as measured by...

Raya Mawad, MD
Swedish Cancer Institute

Flight Attendants Medical Research Institute (FAMRI) – International Early Lung Cancer Action Program (IELCAP) Protocol

Purpose: To assess screening for lung cancer, chronic obstructive pulmonary disease (COPD), cardiac disease, and other diseases in never smokers...

Ralph Aye, M.D.
First Hill Campus

Reducing Health Disparities at End-of-Life

This project will test interactive, web-based training materials designed for health care providers to learn or improve cross-cultural...

Ardith Doorenbos, PhD, RN

I-SPY 2 Trial (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis 2)

The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective...

Erin Ellis, M.D. and Henry Kaplan, M.D.
Swedish Cancer Institute

A Clinical Evaluation of the Safety and Effectiveness of the MitraClip® System for the Treatment of Functional Mitral Regurgitation in Symptomatic Subjects who are Extremely High Risk for Mitral Valve Surgery - COAPT

To evaluate the safety and effectiveness of the MitraClip System for the treatment of moderate-to-severe or severe functional mitral regurgitation...

John Petersen II, MD

A Pivotal Trial to Establish Efficacy and Long-Term Safety of the Parachute Implant System

To evaluate the reasonable assurance of safety and effectiveness of the CKI Parachute implant in the treatment of patients with NYHA Class III or...

Paul Huang, MD

A Post-Approval Study of the LINX® Reflux Management System

Purpose:  This is a prospective, multicenter, single-arm study, with patients as their own control to monitor the safety and efficacy of the LINX...

Brian Louie, M.D.
Swedish Thoracic Surgery / First Hill

Lung Function Improvement after Bronchoscopic Lung Volume Reduction with Pulmonx Endobronchial Valves used in Treatment of Emphysema (LIBERATE STUDY)

Purpose:  This study is designed to investigate the safety and effectiveness of the Pulmonx Endobronchial Valve (EBV) for treating emphysema...

Jed Gorden, M.D.
Swedish Thoracic Surgery / First Hill

CRC 13086: A Study of Heat Shock Protein 90 (HSP90) Inhibitor AT13387 Alone and in Combination with Crizotinib in the Treatment of Non-Small Cell Lung Cancer (NSCLC)

The purpose of the study is to evaluate safety and efficacy of AT13387 Alone and in Combination with Crizotinib in the Treatment of Non-small...

Howard (Jack) West, M.D.
Swedish Cancer Institute

A Study to Evaluate the Safety and Feasibility of Transcranial MRI-Guided Focused Ultrasound Surgery in the Treatment of Brain Tumors.

The purpose of this study it to evaluate the safety of MRI-guided focused ultrasound thermal ablation of brain tumors performed through intact...

Stephen Monteith, MD
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