The Prospective Randomized On-X Valve Anticoagulation Clinical Trial (PROACT)

A longitudinal, randomized study comparing the On-X valve on low dose anticoagulation (test group) to concomitant control groups of On-X valves receiving standard Coumadin/aspirin therapy.

Heart & Vascular - Cardiac Surgery
Eric Lehr, MD

Patients who require either aortic valve replacement or mitral valve replacement (MVR) and who are receiving low dose antiplatelet/anticoagulation therapy. Patients needing both aortic and mitral valves replaced or who have certain diagnoses may be excluded. 

Charlene Boisjolie and Jennifer Nagel