Intravenous acetaminophen for craniotomy patients

Explore if using intravenous acetaminophen just before and just after a craniotomy can reduce the amount of opioids a patient needs, which results in less nausea and vomiting.

Neuroscience - Craniotomy /Interventional, Neuroscience
Arthur M. Lam, M.D.


  • Male or female patients 18 years of age or older.
  • Undergoing an open, elective intracranial procedure for tumor resection aneurysm clipping, or revascularization.
  • Have an ASA (American Society of Anesthesiologists) status of 1, 2, 3, or 4.


  • Have a condition or disease that, in the opinion of the Principal Investigator, would compromise the patient's welfare or safety
  • Current daily chronic opioid use in excess of 40-mg morphine equivalents or any tramadol use.
  • Treated with MAO inhibitors 10 days before surgery.
  • Treated with any amount of acetaminophen within 8 hours of anesthesia.
  • Have known hypersensitivity to acetaminophen or the inactive ingredients of IV acetaminophen or anycontraindication per manufacturer's guidelines.
  • Preganacy
  • Impaired liver function.
  • Participation in an interventional clinical study w...
Becky Wood