When a person has metastatic cancer, the brain is one of the organs that cancer cells can migrate to. If this happens, the condition is called brain metastases. The brain metastases will have the same cancer cell type as the primary cancer, such as lung or breast cancer.
If this occurs, radiation treatment is often used to control these areas of disease. Research is finding that utilizing stereotactic radiosurgery as the initial treatment for people with four or less brain metastases is associated with improved survival and reduced risk of memory loss compared to whole brain radiation. Stereotactic radiosurgery ....
Principal Investigator (PI) for the Cyberknife Breast Protocol
Title: Phase II Study of Accelerated Partial Breast Robotic Intensity Modulated Radiation Therapy for Early Breast Cancer, 2010
Stereotactic Body Radiotherapy: A Practical Guide for the Delivery of Accelerated Partial Breast Irradiation, Sandra Vermeulen, M.D., Huan Giap, M.D. PhD, Cristian Cotrutz, et al, Stereotactic Body Radiotherapy: A Practical Guide (book chapter), 2012
Accelerated Partial Breast Irradiation: Using the CyberKnife as the Radiation Delivery Platform in the Treatment of Early Breast Cancer, Sandra Vermeulen, M.D., Cristian Cotrutz, PhD, Astrid Morris, M.D. et al, Frontiers in Radiation Oncology, 2012
Young RF, Li F, Vermeulen SS, Meier R. Gamma Knife thalamotomy for the treatment of essential tremor:long-term results. J Neurosurg 122:1311-1317, 2010
Publication Pending Young RF, Li F, Vermeulen SS, Meier R. Gamma Knife Pallidotomy for treatment of Parkinson’s disease: Long-term result.
Mayberg M, Vermeulen S: Advances in Stereotactic Radiosurgery in the treatment of Pituitary Adenomas”. Current Opinion in Endocrinology, Diabetes and Obesity, August 2007
Peter D. Grimm, DO*, John Blasko, MD+, Haakon Ragde, MD#, John Sylvester, MD*, William Cavanagh+, Robert Meier, MD*, Sandra Vermeulen, MD*, Paul Stull, MD, James Downey, MD* Alan Tesler, MD, David Hoak, MD: Transperineal Ultrasound Guided I-125/Pd 103 Brachytherapy in the Management of Localized Prostate Cancer: Update of the Clinical Experience at Eight Years
Colman H, Berkey BA, Maor MH, Groves, Schultz CJ, Vermeulen S, Nelson DF, Mehta MP, Yung WK: Radiation Oncology Group> Phase II Radiation Therapy Oncology Group trial of converntioanl radiation therapy followed by treatment with recombinant interferon-beta for supra-tentorial glioblastoma: results of RTOG 9710. International Journal of Radiation Oncology Biology, Ohysic. (3); 818-24 , 2006 Nov 1.
Jones D, Taylor E, Travaglini J, Vermeulen S: A non-contacting intraoperative electron cone apparatus. Int J Rad Onc Biol Phys, 16:1643-1647.
Jones D, Chistopherson D, Hafermann MD, Rieke JR, Travaglini J, Vermeulen S: Experience with a technique for fractionated radiosurgery. (Abstract) Proceedings of the American Society for Therapeutic Radiology and Oncology. Int J Rad Oncol Biol Phys, 1190; 19 (Suppl 1): 134.
Rieke JW, Jones D, Hafermann MD, Vermeulen S, Hughes G, Davies T: The design and construction of individualized perineal templates for combined brachytherapy and hyperthermia. Endocurietherapy/Hyperthermia Oncology, 1989, 5:241-242.
Jones D, Christopherson DS, Washington JT, Hafermann MD, Rieke JW, Vermeulen S, Travaglini J, Taylor E, Taylor W: Practical 3-D radiotherapy planning of brain tumors. Med Dosimetry, 1991; 16:243-249.
Jones D, Christopherson MS, Washington JT, Hafermann MD, Rieke JW, Travaglini J, Vermeulen S: A frameless method for stereotactic radiotherapy. Brit J of Rad, April 1992.
Young RF, Jacques DS, Rand RW, Copcutt BC, Vermeulen S, Posewitz A: Technique of stereotactic medial thalamotomy with the Leksell Gamma Knife for treatment of chronic pain. Neurol Res 1995, 17:59-65.
Young RF, Jacques DS, Rand RW, Copcutt BC, Vermeulen S, Posewitz AE: Medial thalamotomy with the Leksell Gamma Knife for treatment of chronic pain, Advances in Radiosurgery, Acta Neurochirurgica, Supplement 1994;62:105-110.
Young RF, Jacques DS, Rand RW, Copcutt BC, Vermeulen S, Posewitz AE: Technique of stereotactic medical thalamotomy with the Leksell Gamma Knife for treatment of chronic pain, Neurological Research 1995;17:59-65.
Young RF, Jacques DS, Rand RW, Copcutt BC, Vermeulen S, Posewitz AE: Gamma Knife thalamotomy for the treatment of persistent pain, Stereotactic and Functional Neurosurgery, 1995;64:172-181.
Young RF, Vermeulen S, Posewitz AE, Jacques DB, Rand RW, Duma CM, Copcutt BC, Henderson J, Bolles GE, Breese RE, Johnson SD, Pribil SG,: Abstract. Gamma Knife Radiosurgery for Treatment of Multiple Brain Metastases, Sterotact Funct Neurosurg 1995; 64:92-93
Young RF, Jacques DS, Duma C, Rand RW, Henderson J., , Vermeulen S, Grimm P, Blasko J, Posewitz AE, Copcutt B, Bolles GE, Breeze RE, Pribil SG, Winston K, Johnson SD: Gamma Knife radiosurgery for treatment of multiple brain metastases: A comparison of patients with single versus multiple lesions, Radiosurgery,1996; 92-101.
Young RF, Vermeulen S, Posewitz AE, Grimm P, Blasko J, Jacques DB, Rand RW, Copcutt B: Functional neurosurgery with the Leksell Gamma Knife, Radiosurgery, 1996;218-228.
Young RF, Vermeulen S, Grimm P, Posewitz A: Electrophysiological traget localization is not required for the treatment of functional disorders, Sterotact Funct Neurosurg 1996; 66 Suppl 1:320-328.
Kondziolka D, Lunsford LD, Flickinger JC, Young RF, Vermeulen S, Duma CM, Jacques DB, Rand RW, Regis J, Peragut JC, Epstein MH, Lindquist C: Stereotactic radiosurgery for trigeminal neuralgia: A multi-institution study using the Gamma Unit, Journal of Neurosurgery, 1996;84:94-945.
Larson DA, Gutin PH, McDermott M, Lamborn K, Sneed PK, Wara WM, Flickinger JC, Kondziolka D, Lunsford LD, Hudgins WR, Friehs GM, Haselsberger K, Leber K, Pendl G, Chung SS, Coffey RJ, Dinapoli R, Shaw EG, Vermeulen S, Young RF, Hirato M, Inoue HK, Ohye C, Shibazaki T: Gamma Knife for glioma: selection factors and survival. Int J Radiat Oncol Biol Phys, 1996;36:1045-1053.
Young RF, Vermeulen S, Grimm P, Blasko J, Posewitz A: Gamma Knife radiosurgery for treatment of trigeminal neuralgia, Neurology, 1997;48:608-614.
Sehgal A, Keener C, Boyton AL, Young R, Vermeulen S, Yonemura K, Kohler EP, Murphy GP: Characterization of C4-2 as a tumor suppressor gene in human brain tumors, Journal of Surgical Oncology,1997;64:102-108.
Sehgal A, Keener C, Boynton AL, Young RF, Vermeulen S, Yonemura K, Kohler Ep, Murphy GP: Isolation and Characterization of Novel Gen From Human Glioiblastoma Multiforme Tumor Tissue, Int. J. Cancer 1997 May 16; 71(4):565-572.
Sehgal A, Ricks S, Keener C, Boyton AL, Young RF, Vermeulen S, Yonemura K, Kohler EP, Aldape HC, Simrell CR, Murphy GP: Cloning, sequence and developmental expression analysis of C4-2, a potential brain tumor-suppressor gene. Journal of Surgical Oncology,1997;65:249-25.
Vermeulen S, Whole brain radiotherapy in the treatment of metastatic brain tumors. Seminars in Surgical Oncology, 1998;14:64-69.
Vermeulen S Young R, Posewitz A, Grimm P, Blasko J, Kohler E, Raisis J, Stereotactic radiosurgery toxicity in the treatment of intracanalicular acoustic neuromas: The Seattle’s Northwest Gamma Knife Experience, Stereotact and Functional 1998; 70 (Suppl 1) :80-87.
Sehgal A, Boyton AL, Young RF, Vermeulen S, Yonemura KS, Kohler EP, Aldape HC, Simrell CR, Murphy GP, Application of the differential hybridization of atlas human expression arrays technique in the identification of differentially expressed genes in human giobastoma multiforme tumor tissue. Journal of Surgical Oncology, 1998; 67-234-241.
Sehgal A, Boyton AL, Young RF, Vermeulen S, Yonemura KS, Kohler EP, Aldape HC, Simrell CR, Murphy GP: Cell adhesion molecule Nr-CAM is over-expressed in human brain tumors. Int J Cancer 1998 May 18; 76(4):451-458.
Young R, Shumway-Cook A, Vermeulen S, Grimm P, Blasko J, Posewitz A, Burkhart W, Goiney R. Gamma Knife radiosurgery as a lesioning technique in movement disorder surgery. Journal of Neurosurgery, 1999;89: 183-193.
Young RF, Vermeulen S, Posewitz A: Gamma Knife radiosurgery for treatment of trigeminal neuralgia, Stereotact Funct Neurosurg, 1998; 70 (Suppl 1):192-1998.
Young RF, Vermeulen S, Posewitz, Shumway-Cook A: Pallidotomy with the Gamma Knife: A positive experience, Stereotact Funct Neurosurg, 1998; 70 (Suppl 1):80-87.
Vermeulen S, Young R, Li F, Meier R, Raisis J, Klein S, Kohler E: A comparison of single fraction radiosurgery tumor control and toxicity in the treatment of basal and nonbasal meningiomas. Stereotactic and Functional Neurosurgery, 1999; 72 (Suppl 1): 60-66.
Huang M, Vermeulen S: Clinical perspectives regarding patients with internal auditory canal or cerebellopontine angel lesions: surgical and radiation Oncology perspectives. Seminars in Ultrasound, CT, and MRI Vol 24, No 3 (June), 2003: pp 124-132.
Mayberg M, Vermeulen S: Radisurgery in the Treatment of Pituitary Adenomma, J of Endocrinology, 2007 (PENDING)