Intracranial aneurysms are present in up to 4 percent of the population. These potentially dangerous vascular lesions are being detected with increasing frequency in asymptomatic patients by advances in noninvasive imaging techniques, such as magnetic resonance angiography (MRA). Appearing like blisters on the wall of the brain’s blood vessels, aneurysms develop when the blood vessel’s native repair ability is exceeded by the mild, but constant, injury created by flowing blood under high pressure. The five most common risk factors for developing an aneurysm are: smoking, female gender, high blood pressure, middle age and family history.
Intracranial aneurysms are complex lesions that require a highly specialized, multidisciplinary approach that is individualized for each patient. Key members of the care team for these patients include endovascular neuroradiologists, neurosurgeons with special expertise in aneurysm surgery and neuro...
Selected peer-reviewed publications (out of 32).
1.Loh Y and Duckwiler GR. Intracranial mechanical thrombectomy. Surgical Endovascular Neuroradiology. In press.
2.Shi ZS, Loh Y, Liebeskind, DS, Feng L, Jahan R, Gonzalez NR, Tateshima S, Vespa PM, Starkman S, Salamon N, Villablanca P, Ali LK, Ovbiagele B, Kim D, Saver JL, Vinuela F, Duckwiler GR. Leukoaraiosis predicts intracerebral hemorrhage after mechanical thrombectomy in acute ischemic stroke. Stroke; ePub ahead of print.
3.Loh Y, Shi ZS, Liebeskind DS, Jahan R,Tateshima S, Gonzalez N, Vespa PM, Miller C, Starkman S, Saver JL, Vinuela F and Duckwiler GR. Incomplete mechanical recanalization of middle cerebral artery occlusions promotes further ongoing recanalization within 24 hours. J Neurointerv Surg; ePub ahead of print.
4.Loh Y, Liebeskind DS, Shi ZS, Jahan R, Gonzalez NR, Tateshima S, Vespa PM, Starkman S, Saver JL, Vinuela F, Duckwiler GR. Partial recanalization of complex internal carotid – middle cerebral arterial occlusions promotes distal recanalization of residual thrombus within 24 Hours. J Neurointerv Surg 2011; 3: 38-42.
5.Loh Y, Liebeskind DS, Towfighi A, Vespa PM, Starkman S, Saver JL, Gonzalez NR, Tateshima S, Shi Z, Jahan R, Shi ZS, Vinuela F and Duckwiler GR. Pre-Intervention basal ganglionic infarction increases the risk of hemorrhagic transformation but not worse outcome following successfulrecanalization of acute middle cerebral artery occlusions. World Neurosurgery 2010; 74(6): 636-40.
6.Shi ZS, Liebeskind DS, Loh Y, Saver JL, Starkman S, Vespa PM, Gonzalez NR, Tateshima S, Jahan R, Feng L, Miller CM, Ali LK, Ovbiagele B, Kim D, Duckwiler GR, Vinuela F; UCLA Endovascular Stroke Therapy Investigators. Predictors of subarachnoid hemorrhage in acute ischemic stroke with endovascular therapy. Stroke 2010; 41(12): 2775-81.
7.Loh Y, McArthur DL, Vespa PM, Shi ZS, Liebeskind DS, Jahan R, Gonzalez NR, Starkman S, Saver JL, Tateshima S, Duckwiler GR, Fernando Vinuela F. The risk of acute radiocontrast-mediated kidney injury following endovascular therapy for acute ischemic stroke is low. AJNR Am J Neurorad. 2010; 31(9): 1584-7.
8.Loh Y, Duckwiler GR; Onyx Trial Investigators. A prospective, multi-center, randomized trial of Onyx liquid embolic system and N-butyl cyanoacrylate embolization of cerebral arteriovenous malformations. J Neurosurg 2010; 113(4): 733-41.
9.Loh Y, Kim D, Shi ZS, Tateshima T, Vespa PM, Gonzalez NR, Starkman S, Saver JL, Jahan R, Liebeskind DS, Duckwiler GR, Vinuela F. Higher rates of mortality but not morbidity follow intracranial mechanical thrombectomy in the elderly. AJNR Am J Neurorad. 2010; 31(7): 1181-5.
10.Shi ZS, Loh Y, Walker G, Duckwiler GR; MERCI and Multi MERCI Investigators. Endovascular thrombectomy for acute ischemic stroke in failed intravenous tPA versus non-intravenous tPA patients: revascularization and outcomes stratified by the site of arterial occlusions. Stroke. 2010; 41(6): 1185-92.
11.Shi ZS, Loh Y, Walker G, Duckwiler GR; MERCI and Multi MERCI investigators. Clinical outcomes in middle cerebral artery trunk occlusions versus secondary division occlusions after mechanical thrombectomy: pooled analysis of the MERCI and Multi MERCI trials. Stroke. 41(5): 953-60.
12.Loh Y, Towfighi A, Liebeskind DS, MacArthur DL, Vespa PM, Gonzalez NR, Tateshima S, Starkman S, Shi ZS, Jahan R, Vinuela F and Duckwiler GR. Basal ganglionic infarction prior to mechanical thrombectomy predicts poor outcome. Stroke 2009; 40: 3315-20.
13.Shi ZS, Loh Y, Duckwiler GR, Jahan R, Vinuela F. Balloon-assisted transarterial embolization of intracranial dural arteriovenous fistulas. J Neurosurg 2009; 110(5): 921-8.
14.Loh Y, McArthur DL, Jahan R, Duckwiler GR, Vinuela F. Safety of endovascular intracranial aneurysm therapy using three-dimensional rotational angiography: a single center experience. Surg Neurol 2008; 69(2):158-163.
15.Loh Y and Duckwiler GR. Extracranial stenosis: endovascular treatment. Neuroimag Clin N Am 2007; 17(3): 325-36.