Process of Diagnosis
The doctor will ask about your symptoms and medical history. A physical exam will be done.
Tests for Cortisol Levels
- 24-hour urinary free cortisol level-Urine is collected for 24 hours and tested.
- Late-evening cortisol saliva/blood level-Saliva or blood is collected around 11 pm and tested.
- Dexamethasone suppression test-A synthetic cortisol called dexamethasone is taken by mouth; blood and urine samples may be taken overnight or over several days.
Tests to Determine Cause of Cushing's Syndrome
- CRH stimulation test
- ACTH level
- High-dose dexamethasone suppression test
X-rays and Scans
These tests may show whether there is a tumor in the pituitary or adrenal glands or another area of the body. Common imaging tools include:
- MRI scan-a test that uses magnetic waves to make pictures of the inside of the body
- CT scan-a type of x-ray that uses a computer to make pictures of structures inside the body
- Chest x-ray-which may detect tumors in the lungs
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