Research and Innovation Studies

For more than 10 years, Swedish Neuroscience Institute has been at the forefront of innovation in treating chronic neurologic disease. Research projects and publications related to the Center for Neurologic Restoration include:

Current Research

A Continued Access Study to Evaluate the Effectiveness and Safety of Exablate Transcranial MRgFUS Thalamotomy Treatment of Medication Refractory Essential Tremor Subjects
Goal: To evaluate the ongoing safety and efficacy of treatment using the ExAblate Transcranial System in medication-refractory tremor in patients with essential tremor.

EMG and Inertial Measurements of Essential Tremor
Goal: To obtain inertial measurements from post-operative ET patients with the device off and on at two levels of stimulator. This will allow the creation of an accurate pre- and post-operative assessment tool for tremor using a wearable device so we can better identify the most likely patients to respond to DBS treatment. 

DBS Surgery Using a Mobile Intraoperative CT Scan
Goal: To assess the accuracy of the Airo (Brain Lab) intra-operative CT compared that of a fixed CT (SIEMENS) for patients undergoing DBS procedures.

RNS System Post-approval Study in Epilepsy
Goal: To follow patients prospectively over five years in the real-world environment to gather data on the long-term safety and effectiveness of the RNS System at qualified CECs by qualified neurologists, epileptologists and neurosurgeons trained on the RNS System.

A Global Registry to Evaluate Long-Term Effectiveness of Neurostimulation Therapy for Pain
Goal: To compile characteristics of real-world clinical outcomes, economic value and technical performance for Boston Scientific commercially approved neurostimulation systems for pain in routine clinical practice, when used according to the applicable directions for use.

Tissue Procurement and Repository for Future Neuroscience Studies
Goal: Tissue Procurement and Repository for Future Neuroscience Studies

A Pivotal Study to Evaluate the Effectiveness and Safety of ExAblate Transcranial MRgFUS Thalamotomy Treatment of Medication Refractory Essential Tremor Subjects
Goal: To test the safety and initial efficacy of treatment using the ExAblate Transcranial System against a sham control in medication-refractory tremor in patients with essential tremor.
This trial is no longer enrolling patients.

A Feasibility Study to Evaluate Safety and Initial Effectiveness of Exablate Transcranial MR-Guided Focused Ultrasound for Unilateral Thalamotomy in the treatment of Medication-Refractory Tremor Dominant Idiopathic Parkinson's Disease.
Goal: To test the safety and initial efficacy of treatment using the ExAblate Transcranial System against a sham control in medication-refractory tremor in patients with tremor dominant Parkinson’s disease.
This trial is no longer enrolling patients.

Recent Publications

Stephen Monteith, M.D., John Snell, Ph.D., Mathew Eames, Ph.D., Neal Kassell, M.D., Edward Kelly, Ph.D., and Ryder Gwinn, M.D. Transcranial magnetic resonance guided focused ultrasound for temporal lobe epilepsy: a laboratory feasibility study. Accepted, Journal of Neurosurgery.

Alice X Dong, BS*1, Ryder P Gwinn, M.D., Nicole M. Fortier, ARNP, Lisa M. Caylor, M.D., Michael J Doherty, M.D.2, Review: Mitigating Bit Flips in Neurostimulators Mitigating Bit Flips in Neurostimulators. Submitted to: Neuromodulation – Technology at the Neural Interface.

King-Stephens D, Mirro E, Weber PB, Laxer KD, Van Ness PC, Salanova V, Spencer DC, Heck CN, Goldman A, Jobst B, Shields, DC, Bergey GK, Eisenschenk S, Worrell GA, Rossi MA, Gross RE, Cole AJ, Sperling MR, Nair DR, Gwinn RP, Park YD, Rutecki PA, Fountain NB, Wharen RE, Hirsch LJ, Miller IO, Barkley GL, Edwards JC, Geller EB, Berg MJ, Sadler TL, Sun FT, Morrell MJ. Lateralization of mesial temporal lobe epilepsy with chronic ambulatory electrocorticography. Epilepsia. 2015 Jun;56(6):959-67. Epub 2015 May 19.

Bergey GK, Morrell MJ, Mizrahi EM, Goldman A, King-Stephens D, Nair D, Srinivasan S, Jobst B, Gross RE, Shields DC, Barkley G, Salanova V, Olejniczak P, Cole A, Cash SS, Noe K, Wharen R, Worrell G, Murro AM, Edwards J, Duchowny M, Spencer D, Smith M, Geller E, Gwinn R, Skidmore C, Eisenschenk S, Berg M, Heck C, Van Ness P, Fountain N, Rutecki P, Massey A, O'Donovan C, Labar D, Duckrow RB, Hirsch LJ, Courtney T, Sun FT, Seale CG. Long-term treatment with responsive brain stimulation in adults with refractory partial seizures. Neurology. 2015 Feb 24;84(8):810-7. Epub 2015 Jan 23.

Miller-Delaney SF, Bryan K, Das S, McKiernan RC, Bray IM, Reynolds JP, Gwinn R, Stallings RL, Henshall DC. Differential DNA methylation profiles of coding and non-coding genes define hippocampal sclerosis in human temporal lobe epilepsy. Brain. 2015 Mar;138(Pt 3):616-31. Epub 2014 Dec 30.

Heck CN, King-Stephens D, Massey AD, Nair DR, Jobst BC, Barkley GL, Salanova V, Cole AJ, Smith MC, Gwinn RP, Skidmore C, Van Ness PC, Bergey GK, Park YD, Miller I, Geller E, Rutecki PA, Zimmerman R, Spencer DC, Goldman A, Edwards JC, Leiphart JW, Wharen RE, Fessler J, Fountain NB, Worrell GA, Gross RE, Eisenschenk S, Duckrow RB, Hirsch LJ, Bazil C, O'Donovan CA, Sun FT, Courtney TA, Seale CG, Morrell MJ. Two-year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal trial. Epilepsia. 2014 Mar;55(3):432-41. Epub 2014 Feb 22.

Spencer D, Gwinn R, Salinsky M, O'Malley JP. Laterality and temporal distribution of seizures in patients with bitemporal independent seizures during a trial of responsive neurostimulation. Epilepsy Res. 2011 Feb;93(2-3):221-5. Epub 2011 Jan 21.

Kalani MY, Kalani MA, Gwinn R, Keogh B, Tse VC. Embryological development of the human insula and its implications for the spread and resection of insular gliomas. Neurosurg Focus. 2009 Aug;27(2):E2. Review.

Gwinn RP, Spencer DD, Spencer SS, Duckrow RB, Vives K, Wu K, Tkeshelashvili D, Zaveri HP. Local spatial effect of 50 Hz cortical stimulation in humans. Epilepsia. 2008 Sep;49(9):1602-10. Epub 2008 Apr 24. Doherty MJ, Youn C, Gwinn RP, Haltiner AM. Atmospheric pressure and seizure frequency in the epilepsy unit: preliminary observations. Epilepsia. 2007 Sep;48(9):1764-7. Epub 2007 May 1.