Thomas Takyama
Thomas K Takayama, M.D.

Thomas K Takayama, M.D.

Thomas K Takayama, M.D.
Specialty

Urology, Surgery

Clinical Interests / Special Procedures Performed

Renal Cell Cancer, Renal stones, Surgery, Urinary Stone Disease, Urologic Laparoscopic Surgery, Urologic Oncology, Urology

  • Accepting Children: No
  • Accepting New Patients: Yes
  • Accepting Medicare: Yes
  • Accepting Medicaid/DSHS: Unknown
Payment Methods Accepted:

Visa, Mastercard, Discover, Check

Insurance Accepted:

Contact this office for accepted insurance plans.

Additional Information:

Dr. Takayama was voted "Top Doctors" in Seattle Magazine (2012).

A survey was mailed to more than 18,000 physicians in King, Pierce, Snohomish and Kitsap counties. The survey asked physicians to name the provider they would seek out or recommend to loved ones.

News Release

Personal Interests

Family, Fishing, Skiing

Medical School

Tuffs University School of Medicine

Residency

University of Washington

Fellowship(s)

University of Washington: Urologic Oncology

Board Certifications

American Board of Urology

Languages:

English, Japanese

Professional Associations:

American Urological Association, Washington State Medical Association

Awards:

1987 Surgical Infection Society Fellowship

Additional Information:

Dr. Takayama was voted "Top Doctors" in Seattle Magazine (2012).

A survey was mailed to more than 18,000 physicians in King, Pierce, Snohomish and Kitsap counties. The survey asked physicians to name the provider they would seek out or recommend to loved ones.

News Release

1. Miller-Graziano, C., Szabo, G., Takayama, T.K., Interleukin-4 Effects on Monocyte Prostaglandin E2 and Tumor Necrosis Factor. J. Leukocyte Biol. 44, 273 (1988)

2. Miller-Graziano, C., Szabo, G., Takayama, T.K., Wu, J, Alterations of monocyte function following major surgery. In (Faist, E., Ed.) The Immune Consequences of Trauma, Shock and Sepsis. Springer-Verlag, pp.95-109.(1989)

3. Zappala, S., Khauli, R., Miller-Graziano, C., Stoff, J., Takayama, T.K., Menon, M., Evaluation of Monocyte Procoagulant Activity as a Parameter for Immunological Monitoring in Renal Transplantation. Transplant Proc. 21, 1844-1855 (1989)

4. Szabo, G., Miller-Graziano, C., Wu, J., Takayama, T.K., Kodys, K., Differential Tumor Necrosis Factor Production by Human Monocyte Subsets. J. Leukocyte Biol. 47, 206-216 (1990)

5. Takayama, T.K., Miller-Graziano, C., Szabo, G., Elevated Tumor Necrosis Factor Production Concomitant to Elevated Prostaglandin E2 Production by Trauma Patients' Monocytes. Arch. Surg. 125, 29-35 (1990)

6. Riley, D.E., Roberts, M.C., Takayama, T.K., Krieger, J.N., Development of a Polymerase Chain Reaction-Based Diagnosis of Trichimonas Vaginalis. J. Clin. Microbiol. 30, 465-472 (1992)

7. Takayama, T.K., Krieger, J.N., True, L.D., Lange, P.H., Recurrent Prostate Cancer Despite Undetectable Prostate Specific Antigen. J. Urol. 148, 1541-1542 (1992)

8. Takayama, T.K., and Brawer, M.K., Prostate Ultrasonography, Normal and Benign Conditions. World J. Urology. 10(4):198-202 (1992)

9. Takayama, T.K., Vessella, R.L., Brawer, M.K., Noteboom,J., and Lange, P.H., The enhanced detection of persistent disease after radical prostatectomy with a new prostate specific antigen (PSA) immunoassay. J. Urol. 150(2): 374-378 (1993)

10. Takayama, T.K., Vessella, R.L., and Lange, P.H., A brief review of ultrasensitive prostate-specific antigen assays for the evaluation of patients after radical prostatectomy. World J. Urology. 11(4):192-195 (1993)

11. Takayama, T.K., Vessella, R.L., Brawer, M.K., Noteboom,J., and Lange, P.H., Urinary prostate specific antigen levels after radical prostatectomy. J. Urol. 151(1):82-87. (1994)

12. Takayama, T.K., Vessella, R.L., and Lange, P.H., Newer Applications of serum prostate specific antigen in the management of prostate cancer. Seminars in Oncology, 21(5):542-553 (1994)

13. Takayama, T.K. and Lange, P.H., Radiation therapy for local recurrence of prostate cancer after radical prostatectomy. Urol. Clin. N. Amer., 21(4):687-700 (1994)

14. Takayama, T.K. and Lange, P.H., Prostate carcinoma (counterpoint) in Cancer Patient Follow-up, Johnson, F.E and Virgo, K.S., eds., Mosby-Year Book, Inc., pp.400-405 (1997)

15. Porter, J.R. Takayama, T.K. and Defalco, A.J. Traumatic posterior urethral injury and early realignment using magnetic urethral catheters. J Urol. 158(2):425-30 (1997)

16. Takayama, T.K., Fujikawa, K. and Davie, E.W., Characterization of the precursor of prostate specific antigen: activation by trypsin and human glandular kallikrein. J. Biol. Chem. 272(34):21582-21588 (1997)

17. Takayama, T.K., Carter, C.A. and Deng, T. Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR. Biochemistry, 40(6): 1679-1687 (2001)

18. Cooley, J., Takayama, T.K., Schechter, N.M. and Remold-O’Donnell, E. The serpin MNEI inhibits elastase-like chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry, 40(51): 15762-70 (2001)

19. Zheng, X., Chung, D., Takayama, T.K., Majerus, E.M., Sadler, J.E. and Fujikawa, K. Structure of von Willebrand factor cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J. Biol. Chem., 276(44): 41059-63 (2001)

20. Takayama, T.K., McMullen, B.A., Nelson, P.S., Matsumura, M. and Fujikawa, K. Characterization of hK4 (prostase), a prostate specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase. Biochemistry, 40(50): 15341-8 (2001)

21. Greenberg, D.L., Mize, G.J., and Takayama, T.K. Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells. Biochemistry, 42(3): 702-9 (2003)

22. Black PC, Lange PH, Takayama, T.K. Extensive palliative surgery for advanced mesothelioma of the tunica vaginalis. Urology, 62(4): 748 (2003)

23. Matsumura, M., Bhatt, A.S., Andress, D., Clegg, N., Takayama, T.K., Craik, C.S., Nelson, P.S. Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries. Prostate. 62(1):1-13 (2005).

24. Cuevas C, Raske M, Bush WH, Takayama T, Maki JH, Kolokythas O, Meshberg E. Imaging primary and secondary tumor thrombus of the inferior vena cava: multi-detector computed tomography and magnetic resonance imaging. Curr Probl Diagn Radiol. May-Jun;35(3):90-101 (2006) May.

25. Sim HG, Kliot M, Lange PH, Ellis WJ, Takayama TK, Yang CC. Two-year outcome of unilateral sural nerve interposition graft after radical prostatectomy. Urology. Dec;68(6):1290-4 (2006) Dec.

26. Dighe M, Takayama T, Bush WH Jr. Preoperative planning for renal cell carcinoma--benefits of 64-slice CT imaging. Int Braz J Urol. 33(3):305-12 (2007) May.

27. Black, PC, Mize, GJ, Karlin, P, Greenberg, DL, Hawley, SJ, True, LD, Vessella, RL, and Takayama, TK. Over-expression of Protease-Activated Receptors-1,-2 and-4 (PAR-1, -2, and -4) in prostate cancer. The Prostate 67(7):743-56 (2007) May.

28. Kenerson1 H, Folpe A, Takayama TK, Yeung RS. Activation of the mTOR pathway in sporadic angiomyolipomas and PEComas. Human Pathology 38(9):1361-71 (2007) Sep.

29. Mize GJ, Wang W, Takayama TK. Prostate-Specific Kallikreins-2 and -4 Enhance the Proliferation of DU-145 Prostate Cancer Cells through Protease-Activated Receptors-1 and -2. Mol Cancer Res. 6(6):1043-51 (2008) Jun.

30. Wang W, Zhang X, Mize GJ, Takayama TK. Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. The Prostate. 68(10):1064-75 (2008) Jul.

31. Mize GJ, Harris JE, Takayama TK, Kulman JD. Regulated expression of active biotinylated G-protein coupled receptors in mammalian cells. Protein Expr Purif. 57(2):280-9 (2008) Feb.

32. Wang W, Zhang X, Mize GJ, Takayama TK. Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. Prostate. 2008 Jul 1;68(10):1064-75.

33. Mize GJ, Wang W, Takayama TK. Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2. Mol Cancer Res. 2008 Jun;6(6):1043-51.

34. Zhang X, Wang W, True LD, Vessella RL, Takayama TK. Protease-activated receptor-1 is upregulated in reactive stroma of primary prostate cancer and bone metastasis. Prostate. 2009 May 15;69(7):727-36.

35. Swedberg JE, Nigon LV, Reid JC, de Veer SJ, Walpole CM, Stephens CR, Walsh TP, Takayama TK, Hooper JD, Clements JA, Buckle AM, Harris JM. Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4. Chem Biol. 2009 Jun 26;16(6):633-43.

36. Pascal LE, Goo YA, Vêncio RZ, Page LS, Chambers AA, Liebeskind ES, Takayama TK, True LD, Liu AY. Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes. BMC Cancer. 2009 Sep 8;9:317.

37. Wang W, Mize GJ, Zhang X, and Takayama TK. Kallikrein-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1. International Journal of Cancer. 2010 Feb 1;126(3):599-610.

Offices

Issaquah Campus
751 N.E. Blakely Dr.
Issaquah, WA 98029
Phone: 425-313-4000
If calling after hours, please specify you are looking for the Issaquah campus.
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Washington Urology Associates, PLLC
1135 NE 116th Ave
Suite 620
Bellevue, WA 98004
Phone: 425-454-8016
Fax: 425-453-2827

Monday through Friday 8:00am-5:00pm


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