Thomas Ken Takayama, MD

  • Urology
Accepting New Patients
Washington Urology Associates, PLLC
1135 NE 116th Ave
Suite 620
Bellevue 98004

General Information

  • Urology
Education Background
Medical School: Tufts University School of Medicine, 1985
Residency: University of Washington, Dept of Urology
Fellowship: University of Washington, Urologic Oncology
  • English
  • Japanese
Professional Associations
American Urological Association, Washington State Medical Association
Personal Interests
Family, Fishing, Skiing



1. Miller-Graziano, C., Szabo, G., Takayama, T.K., Interleukin-4 Effects on Monocyte Prostaglandin E2 and Tumor Necrosis Factor. J. Leukocyte Biol. 44, 273 (1988)

2. Miller-Graziano, C., Szabo, G., Takayama, T.K., Wu, J, Alterations of monocyte function following major surgery. In (Faist, E., Ed.) The Immune Consequences of Trauma, Shock and Sepsis. Springer-Verlag, pp.95-109.(1989)

3. Zappala, S., Khauli, R., Miller-Graziano, C., Stoff, J., Takayama, T.K., Menon, M., Evaluation of Monocyte Procoagulant Activity as a Parameter for Immunological Monitoring in Renal Transplantation. Transplant Proc. 21, 1844-1855 (1989)

4. Szabo, G., Miller-Graziano, C., Wu, J., Takayama, T.K., Kodys, K., Differential Tumor Necrosis Factor Production by Human Monocyte Subsets. J. Leukocyte Biol. 47, 206-216 (1990)

5. Takayama, T.K., Miller-Graziano, C., Szabo, G., Elevated Tumor Necrosis Factor Production Concomitant to Elevated Prostaglandin E2 Production by Trauma Patients' Monocytes. Arch. Surg. 125, 29-35 (1990)

6. Riley, D.E., Roberts, M.C., Takayama, T.K., Krieger, J.N., Development of a Polymerase Chain Reaction-Based Diagnosis of Trichimonas Vaginalis. J. Clin. Microbiol. 30, 465-472 (1992)

7. Takayama, T.K., Krieger, J.N., True, L.D., Lange, P.H., Recurrent Prostate Cancer Despite Undetectable Prostate Specific Antigen. J. Urol. 148, 1541-1542 (1992)

8. Takayama, T.K., and Brawer, M.K., Prostate Ultrasonography, Normal and Benign Conditions. World J. Urology. 10(4):198-202 (1992)

9. Takayama, T.K., Vessella, R.L., Brawer, M.K., Noteboom,J., and Lange, P.H., The enhanced detection of persistent disease after radical prostatectomy with a new prostate specific antigen (PSA) immunoassay. J. Urol. 150(2): 374-378 (1993)

10. Takayama, T.K., Vessella, R.L., and Lange, P.H., A brief review of ultrasensitive prostate-specific antigen assays for the evaluation of patients after radical prostatectomy. World J. Urology. 11(4):192-195 (1993)

11. Takayama, T.K., Vessella, R.L., Brawer, M.K., Noteboom,J., and Lange, P.H., Urinary prostate specific antigen levels after radical prostatectomy. J. Urol. 151(1):82-87. (1994)

12. Takayama, T.K., Vessella, R.L., and Lange, P.H., Newer Applications of serum prostate specific antigen in the management of prostate cancer. Seminars in Oncology, 21(5):542-553 (1994)

13. Takayama, T.K. and Lange, P.H., Radiation therapy for local recurrence of prostate cancer after radical prostatectomy. Urol. Clin. N. Amer., 21(4):687-700 (1994)

14. Takayama, T.K. and Lange, P.H., Prostate carcinoma (counterpoint) in Cancer Patient Follow-up, Johnson, F.E and Virgo, K.S., eds., Mosby-Year Book, Inc., pp.400-405 (1997)

15. Porter, J.R. Takayama, T.K. and Defalco, A.J. Traumatic posterior urethral injury and early realignment using magnetic urethral catheters. J Urol. 158(2):425-30 (1997)

16. Takayama, T.K., Fujikawa, K. and Davie, E.W., Characterization of the precursor of prostate specific antigen: activation by trypsin and human glandular kallikrein. J. Biol. Chem. 272(34):21582-21588 (1997)

17. Takayama, T.K., Carter, C.A. and Deng, T. Activation of prostate-specific antigen precursor (pro-PSA) by prostin, a novel human prostatic serine protease identified by degenerate PCR. Biochemistry, 40(6): 1679-1687 (2001)

18. Cooley, J., Takayama, T.K., Schechter, N.M. and Remold-O’Donnell, E. The serpin MNEI inhibits elastase-like chymotrypsin-like serine proteases through efficient reactions at two active sites. Biochemistry, 40(51): 15762-70 (2001)

19. Zheng, X., Chung, D., Takayama, T.K., Majerus, E.M., Sadler, J.E. and Fujikawa, K. Structure of von Willebrand factor cleaving protease (ADAMTS13), a metalloprotease involved in thrombotic thrombocytopenic purpura. J. Biol. Chem., 276(44): 41059-63 (2001)

20. Takayama, T.K., McMullen, B.A., Nelson, P.S., Matsumura, M. and Fujikawa, K. Characterization of hK4 (prostase), a prostate specific serine protease: activation of the precursor of prostate specific antigen (pro-PSA) and single-chain urokinase-type plasminogen activator and degradation of prostatic acid phosphatase. Biochemistry, 40(50): 15341-8 (2001)

21. Greenberg, D.L., Mize, G.J., and Takayama, T.K. Protease-activated receptor mediated RhoA signaling and cytoskeletal reorganization in LNCaP cells. Biochemistry, 42(3): 702-9 (2003)

22. Black PC, Lange PH, Takayama, T.K. Extensive palliative surgery for advanced mesothelioma of the tunica vaginalis. Urology, 62(4): 748 (2003)

23. Matsumura, M., Bhatt, A.S., Andress, D., Clegg, N., Takayama, T.K., Craik, C.S., Nelson, P.S. Substrates of the prostate-specific serine protease prostase/KLK4 defined by positional-scanning peptide libraries. Prostate. 62(1):1-13 (2005).

24. Cuevas C, Raske M, Bush WH, Takayama T, Maki JH, Kolokythas O, Meshberg E. Imaging primary and secondary tumor thrombus of the inferior vena cava: multi-detector computed tomography and magnetic resonance imaging. Curr Probl Diagn Radiol. May-Jun;35(3):90-101 (2006) May.

25. Sim HG, Kliot M, Lange PH, Ellis WJ, Takayama TK, Yang CC. Two-year outcome of unilateral sural nerve interposition graft after radical prostatectomy. Urology. Dec;68(6):1290-4 (2006) Dec.

26. Dighe M, Takayama T, Bush WH Jr. Preoperative planning for renal cell carcinoma--benefits of 64-slice CT imaging. Int Braz J Urol. 33(3):305-12 (2007) May.

27. Black, PC, Mize, GJ, Karlin, P, Greenberg, DL, Hawley, SJ, True, LD, Vessella, RL, and Takayama, TK. Over-expression of Protease-Activated Receptors-1,-2 and-4 (PAR-1, -2, and -4) in prostate cancer. The Prostate 67(7):743-56 (2007) May.

28. Kenerson1 H, Folpe A, Takayama TK, Yeung RS. Activation of the mTOR pathway in sporadic angiomyolipomas and PEComas. Human Pathology 38(9):1361-71 (2007) Sep.

29. Mize GJ, Wang W, Takayama TK. Prostate-Specific Kallikreins-2 and -4 Enhance the Proliferation of DU-145 Prostate Cancer Cells through Protease-Activated Receptors-1 and -2. Mol Cancer Res. 6(6):1043-51 (2008) Jun.

30. Wang W, Zhang X, Mize GJ, Takayama TK. Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. The Prostate. 68(10):1064-75 (2008) Jul.

31. Mize GJ, Harris JE, Takayama TK, Kulman JD. Regulated expression of active biotinylated G-protein coupled receptors in mammalian cells. Protein Expr Purif. 57(2):280-9 (2008) Feb.

32. Wang W, Zhang X, Mize GJ, Takayama TK. Protease-activated receptor-1 upregulates fibroblast growth factor 7 in stroma of benign prostatic hyperplasia. Prostate. 2008 Jul 1;68(10):1064-75.

33. Mize GJ, Wang W, Takayama TK. Prostate-specific kallikreins-2 and -4 enhance the proliferation of DU-145 prostate cancer cells through protease-activated receptors-1 and -2. Mol Cancer Res. 2008 Jun;6(6):1043-51.

34. Zhang X, Wang W, True LD, Vessella RL, Takayama TK. Protease-activated receptor-1 is upregulated in reactive stroma of primary prostate cancer and bone metastasis. Prostate. 2009 May 15;69(7):727-36.

35. Swedberg JE, Nigon LV, Reid JC, de Veer SJ, Walpole CM, Stephens CR, Walsh TP, Takayama TK, Hooper JD, Clements JA, Buckle AM, Harris JM. Substrate-guided design of a potent and selective kallikrein-related peptidase inhibitor for kallikrein 4. Chem Biol. 2009 Jun 26;16(6):633-43.

36. Pascal LE, Goo YA, V�ncio RZ, Page LS, Chambers AA, Liebeskind ES, Takayama TK, True LD, Liu AY. Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes. BMC Cancer. 2009 Sep 8;9:317.

37. Wang W, Mize GJ, Zhang X, and Takayama TK. Kallikrein-4 initiates tumor-stroma interactions in prostate cancer through protease-activated receptor-1. International Journal of Cancer. 2010 Feb 1;126(3):599-610.

Clinical Experience

  • Urology
Clinical Interests
  • asymptomatic bacturia
  • atony urinary bladder
  • balanitis
  • balanoposthitis
  • benign prostatic hypertrophy
  • biopsy of penis
  • biopsy of periurethral tissue
  • biopsy of scrotum or tunica vaginalis
  • biopsy of urethra
  • bladder disease
  • bladder diverticulum
  • bladder exstrophy
  • bladder fistula
  • bladder hemorrhage
  • bladder neck obstruction
  • bladder sphincterotomy
  • bladder trauma
  • bph surgery
  • catheter
  • circumcision
  • condylomata acuminata
  • congenital anomaly of urinary system
  • continuous leakage of urine
  • crushing injury of external genitalia
  • cystectomy
  • cystogram
  • cystometry
  • cystoscopy
  • cystoureterostomy
  • cystourethroscopy
  • cystourethrostomy
  • detrusor instability
  • dilatation of ureter
  • dilation of ureteral meatus
  • dysplasia of prostate
  • ectopic ureter
  • edema of male genital organs
  • edema of penis
  • elevated psa
  • encysted hydrocele
  • enlarged prostate
  • enterovesical fistula
  • epididymal cyst removal
  • epididymal mass
  • epididymectomy
  • epididymitis
  • epididymo-orchitis
  • epididymotomy
  • epispadias
  • female genital problems
  • foreign body in genitourinary tract
  • foreign body in penis
  • frenulotomy of penis
  • frequency of urination
  • frequent urinary tract infections
  • frostbite of penis
  • functional incontinence
  • genital herpes, female
  • genital herpes, male
  • granuloma inguinale
  • groin mass
  • hematuria
  • hydrocele
  • hydrocelectomy
  • hypoplasia of penis
  • hypospadias
  • ileal conduit
  • increased frequency of micturition
  • infected hydrocele
  • infection of cystostomy
  • infection of kidney
  • insertion of testicular prosthesis
  • interstim
  • interstitial cystitis
  • intra-lesional therapy for peyronie's disease
  • kidney injury
  • kidney malformation
  • kidney stone
  • laparoscopic urology
  • lichen sclerosus of penis
  • lysis of penile adhesions
  • male genital organ stricture
  • male genital problems
  • meatal stenosis
  • micropenis
  • microscopic hematuria
  • mixed incontinence
  • nephrectomy
  • nephropexy
  • nephrostomy
  • nephrotomy
  • nephroureterectomy
  • neurogenic urinary bladder
  • nocturia
  • nontraumatic rupture of bladder
  • open pyeloplasty
  • overactive bladder
  • overflow incontinence of urine
  • painful bladder syndrome
  • paralysis of bladder
  • partial cystectomy
  • partial nephrectomy
  • partial orchiectomy
  • penile bleeding
  • penile chordee
  • penile discharge
  • penile fibrosis
  • penile hypoplasia
  • penile hypospadias
  • penile induration
  • penile leukoplakia
  • penile plaque
  • penile prosthesis
  • penis
  • penis straightening chordee
  • periurethral abscess
  • peyronie's
  • phimosis
  • plastic urethral sphincter
  • polyuria
  • post prostatectomy erectile impairment
  • post-prostatectomy incontinence
  • post-void dribbling
  • post-void residual
  • prostate abscess
  • prostate bleeding
  • prostate examination
  • prostate infection
  • prostate specific antigen
  • prostatic atrophy
  • prostatic cyst
  • prostatic hyperplasia
  • prostatic hypertrophy
  • prostatic massage
  • prostatitis
  • pyelitis
  • pyelonephritis
  • pyeloscopy
  • pyelostomy
  • radiation cystitis
  • radioactive seed implants
  • reconstruction of urethra
  • rectourethral fistua
  • recurrent urinary tract infection
  • release of chordee
  • removal of internal penile prosthesis
  • renal cortical necrosis
  • renal denervation
  • renal disease and pregnancy
  • repair of rectourethral fistula
  • replacement of ureterostomy tube
  • reversal of vasectomy
  • screening for malignant neoplasms of prostate
  • screening for malignant neoplasms of testis
  • scrotal abscess
  • scrotal cyst
  • scrotal disorder
  • scrotal mass
  • scrotal pain
  • scrotectomy
  • semen abnormality
  • sexually transmitted diseases
  • slowing of urinary stream
  • spermatic cord torsion
  • spermatocele
  • spermatocele aspiration
  • straining on urination
  • stress incontinence
  • stretching of prepuce
  • swollen penis
  • testicular atrophy
  • testicular hydrocele
  • testicular pain
  • testopel treatment
  • total incontinence
  • transgender surgery
  • transurethral balloon dilation of prostatic urethra
  • transurethral cystoscopy
  • transurethral prostatectomy
  • unilateral orchidectomy
  • ureter
  • ureteral meatotomy
  • ureteral stent
  • ureterectomy
  • ureteric fistula
  • ureteric obstruction
  • ureterocele
  • ureteroenterostomy
  • ureterolithotomy
  • ureteropelvic junction obstruction
  • ureteroplasty
  • ureterotomy
  • urethra
  • urethral abscess
  • urethral caruncle
  • urethral discharge
  • urethral diverticulum
  • urethral false passage
  • urethral fistula
  • urethral polyps
  • urethral stenosis
  • urethral stricture
  • urethral syndrome
  • urethrocystopexy
  • urethromeatoplasty
  • urethropexy
  • urethrotomy
  • urinary diversion
  • urinary hesitation
  • urinary retention
  • urinary tract infection
  • urinary tract injury
  • urinary tract malformation
  • urinary tract obstruction
  • urinary urgency
  • urine
  • uroflowmetry
  • varicocele
  • vasectomy
  • vesicocutaneous fistula
  • vesicoureteral reflux
  • video urodynamic
  • voiding dysfunction
Washington Urology Associates, PLLC
1135 NE 116th Ave
Suite 620
Bellevue, 98004
Affiliated Facilities