Pavle Repovic
Pavle Repovic, MD, PhD

Pavle Repovic, MD, PhD

Pavle Repovic, MD, PhD
Specialty

Multiple Sclerosis, Neurology

Clinical Interests / Special Procedures Performed

Autoimmune Disorders, Clinical Research & Educ., Clinical Trials, Double Vision, Immunology, Limb Numbness, Multiple Sclerosis, Multiple Sclerosis Clinics at SNI, Neuroimmunology, Swedish Neuroscience Institute

  • Accepting Children: Unknown
  • Accepting New Patients: Yes
  • Accepting Medicare: Yes
  • Accepting Medicaid/DSHS: Yes
Payment Methods Accepted:

Bill insurance, Cash, Check, MasterCard, Payment plan, Sliding fee scale, Visa

Insurance Accepted:

Contact this office for accepted insurance plans.

Additional Information:

Dr. Repovic was voted "Top Doctors" in Seattle Metropolitan Magazine (2011, 2012, 2013)

Physicians, nurses and physician assistants in King, Kitsap and Snohomish counties nominated colleagues they would choose to treat themselves and their loved ones.

News Release

Philosophy of Care

Offering my patients the guidance and support to effectively manage their condition and lead a fuller life

Personal Interests

foreign languages, cultures and cuisine; tango; nature

Medical School

University of Alabama School of Medicine

Residency

Cornell - New York Presbyterian Hospital

Fellowship(s)

Mount Sinai Hospital, New York

Board Certifications

American Board of Psychiatry and Neurology

Languages:

English, Serbo-Croatian, Spanish

Professional Associations:

Diplomate, American Board of Psychiatry and Neurology; Member, American Academy of Neurology

Awards:

Sylvia Lawry Fellowship (2008-2010, National MS Society); Young Investigator Fellowship (2002, International Society for Neurochemistry)

Additional Information:

Dr. Repovic was voted "Top Doctors" in Seattle Metropolitan Magazine (2011, 2012, 2013)

Physicians, nurses and physician assistants in King, Kitsap and Snohomish counties nominated colleagues they would choose to treat themselves and their loved ones.

News Release

Peer-reviewed original contributions:
1) Repovic P, Lublin F (2010) Treatment of multiple sclerosis exacerbations. Neurol Clinics North America, in press.
2) Repovic P, Fears C, Gladson CL, Benveniste EN (2003) Oncostatin-M induction of vascular endothelial growth factor expression in astroglioma cells. Oncogene 22(50), 8117-24.
3) Repovic P, Mi K, Benveniste EN (2003) Oncostatin M enhances the expression of prostaglandin E2 and cyclooxygenase-2 in astrocytes: synergy with interleukin-1beta, tumor necrosis factor-alpha and bacterial LPS. Glia 42(4), 433-46.
4) Repovic P, Benveniste EN (2002) Prostaglandin E2 is a novel inducer of Oncostatin M expression in macrophages and microglia. J Neurosci 22(13), 5334-43.
5) Van Wagoner NJ, Choi C, Repovic P, Benveniste EN (2000) Oncostatin M regulation of interleukin-6 expression in astrocytes: biphasic regulation involving the mitogen-activated protein kinases ERK1/2 and p38. J Neurochem 75(2), 563-75.
6) Van Wagoner NJ, Oh JW, Repovic P, Benveniste EN (1999) IL-6 production by astrocytes:autocrine regulation by IL-6 and soluble IL-6 receptor. J Neurosci 19(13), 5236-44.
7) Waddel TG, Repovic P, Melendez-Hevia E, Heinrich R, Montero F (1997) Optimisation of glycolysis: a new look at the efficiency of energy coupling; Biochem Educ 25(4), 204-205.


Books and Chapters:
• Repovic P. Molecular Neurobiology and Neurotrauma chapters in the 2006 Psychiatry In-Review Study Guide, ed. S. J. Ferrando, ETAS. New York, 2006

A (Slightly) New Medication for Multiple Sclerosis Comes Out in November

Interferons have been used for the treatment of multiple sclerosis (MS) since 1993. The existing line-up of interferons for MS (Avonex, Betaseron, Extavia and Rebif) will soon be joined by Plegridy, approved by the US Food and Drug Administration in August 2014. Plegridy will become commercially available in November 2014.

Plegridy is a pegylated form of interferon beta. Pegylation is a process, used by several other non-MS medications, whereby a long string of polyethylene glycol molecules is attached to the interferon beta molecule, to extend its half-life by reducing clearance via kidneys or other elimination pathways in the body. This modification allows less frequent dosing of Plegridy – once every two weeks – although it is still administered as an injection under the skin.

In the ADVANCE trial, Plegridy was ..

FDA declines approval of Lemtrada for the treatment of MS

On December 30, 2013, the US Food and Drug Administration declined to approve the use of alemtuzumab (Lemtrada) for the treatment of multiple sclerosis. The FDA stated that the manufacturer of Lemtrada “has not submitted evidence from adequate and well-controlled studies that demonstrate the benefits of Lemtrada outweigh its serious adverse effects.” This was a surprising decision to some, as only a month earlier an advisory panel of experts convened by the FDA, while raising some objections, voted to have this medicine approved. The manufacturer of Lemtrada, Genzyme, a Sanofi company, intends to appeal this decision.
 
In response, a number of MS organizations and experts have voiced their concerns that with this step, MS patients are left without a potential choice in therapy. This decision is particularly difficult for ...

2013 World Atlas of MS published

The 2013 World Atlas of MS has been published by MS International Foundation and is available here. The key findings are:

  1. The estimated number of people with MS has increased from 2.1 million in 2008 to 2.3 million in 2013
  2. The 2:1 ratio of women to men with MS has not changed significantly since 2008
  3. Substantial global inequalities remain in terms of access to treatment and medical care

Is someone with multiple sclerosis an MSer?

A survey from the United Kingdom published in the Journal of MS and Related Disorders polled 396 people with multiple sclerosis (MS) about how they would like to be referred to in conversation. The winning term ("MSer") was supported by 43% of the respondents, while "person with MS" received 34% votes. When a United States-based blog reported on the story, 2 out of 3 respondents disagreed.

What do you think? Comment below with your preference and why.

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(Ed. note: You can comment anonymously - feel free to use your initials if you are more comfortable sharing that way.)

MS Research Roundup: Cannabinoids and new trials for progressive MS

A couple recent announcements may be of interest to people living with multiple sclerosis. Read the articles below and click through the links for more information about the individual studies.

Trial shows no benefit of cannabinoid in slowing multiple sclerosis progression

A UK trial of dronabinol (delta-9-THC) in 498 patients did not slow the progression of multiple sclerosis (MS) compared to placebo. Critics will point out that this is only one of many cannabinoids found in marijuana; and that the placebo arm did better than expected (thus limiting the ability to detect the effects of the drug). Nonetheless, the result is the strongest argument yet against the neuroprotective effects of THC in MS population.

New trials in progressive MS are coming

Later this year, two trials will ...

MS Research Update: New MS tests could improve predictions of cognitive impairment

Cognitive dysfunction in multiple sclerosis (MS) is a recognized, but poorly understood phenomenon. Detection of cognitive dysfunction is hampered by the fact that cognitive testing is often long, sometimes costly and at times frustrating for patients. A brief, acceptable screening tool for cognitive dysfunction in MS is lacking.

A new study shows potential progress toward such a tool. Authors of a paper published in the Multiple Sclerosis Journal describe a 10-minute battery of computerized tests that was able to identify with fairly good sensitivity those patients who experienced cognitive impairment. This study, like several other similar efforts, awaits verification before they are more broadly accepted. It is hoped that such tools will come at no or minimal cost to the patients.

Identifying cognitive dysfunction early may be important because, according to a second study published in Neurology, early treatment is more likely to ...

Swedish Contributes to New Treatment Option for Multiple Sclerosis

 On September 12, 2012, the Food and Drug Administration (FDA) approved teriflunomide for the treatment of multiple sclerosis (MS). Teriflunomide (AUBAGIO) is a once-daily pill for the treatment of relapsing forms of MS. Led by Dr. Lily Jung Henson, the Swedish Neuroscience Institute was among several clinical sites that tested the drug. Results of the research showed that teriflunomide can lessen MS disease activity. Specifically, it behaves similarly to injectable therapies by slowing MS relapse frequency, the rate of disability and MRI activity.

The safety profile, however, is more challenging than ....

Results 1-7 of 8

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Multiple Sclerosis Center
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Phone: 206-320-2800
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