John W Henson IV
John W Henson IV, MD, MBA, FAAN

John W Henson IV, MD, MBA, FAAN

John W Henson IV, MD, MBA, FAAN
Specialty

Neurology, Neuro-Oncology, Radiology

Clinical Interests / Special Procedures Performed

Astrocytoma, Cancer Institute, Chemotherapy/Radiation Therapy, Chordoma, Clinical Trials, Computer Imaging, Glioblastoma, Lumbar Punctures, Meningioma, MRI, Neurology, Neuro-oncology, Schwannoma, Spine Tumor/AVM Embolization

  • Accepting Children: Yes
  • Accepting New Patients: Yes
  • Accepting Medicare: Yes
  • Accepting Medicaid/DSHS: Yes
Payment Methods Accepted:

Medicare, Medicaid/DSHS, Bill Insurance, VISA, Master Card, Cash, Check, Payment Plan, American Express, Billing Service, Discover Card, Money Order, Pending, Purchase Order, Sliding Fee Scale

Insurance Accepted:

Contact this office for accepted insurance plans.

Additional Information:

Curriculum Vitae


John William Henson IV, MD, MBA, FAAN, FANA
      
Vice President of Medical Affairs
Swedish Medical Center, Cherry Hill campus
Neuro-oncologist
Neuroradiologist
Swedish Medical Center

Administrative Address -  Swedish Medical Center, Cherry Hill
500 17th Avenue, Professional Building, Suite 402
Seattle, WA 98122
Telephone: 206-320-2057
Fax: 206-320-3153
    
Clinical Address - Ivy Center for Advanced Brain Tumor Treatment
550 17th Avenue, Suite 540
Seattle, WA 98122
Telephone: 206-320-2300

Place and Date of Birth  Chattanooga, Tennessee
January 3, 1958

Education  

1980  BA   Southern Adventist University, Collegedale, TN

1984  MD    Loma Linda University School of Medicine, Loma Linda, CA

2013  MBA  University of Washington Foster School of Business

Postdoctoral Training

1984-85 Intern    
Internal Medicine   Loma Linda University Medical Center

1985-88 Resident   
Neurology    Vanderbilt University Medical Center

1987-88 Chief Resident 
Neurology    Vanderbilt University Medical Center

1988-91 Fellow   
Neuro-oncology  Memorial Sloan-Kettering Cancer Center 

1990-91 Clinical Scholars 
Neuro-oncology  Biomedical Research Training Program
Fellow Memorial Sloan-Kettering Cancer Center/NCI

1990  Summer Student Neurobiology  
Cold Spring Harbor Laboratory
Program in  Neurobiology

1999  Student  
Managing Technical Sloan School of Management 
Professionals and  Executive Program
Massachusetts Institute of Technology

1999  Student  
IT for the non-IT Executive
Sloan School of Management Executive
Program, Massachusetts Institute of Technology

2000  Student  
Enhancing Executive Influence 
John F. Kennedy School of Government
Harvard University

2000  Student   Leadership Development for Physicians in Academic Health Centers
Harvard School of Public Health
Harvard University

2001  Student  Primer: Philanthropy 
New England Association for Healthcare Philanthropy

2001-03 Fellow  Diagnostic  Neuroradiology 
Massachusetts General Hospital, Division of Neuroradiology

2008  Fellow  Palatucci Advocacy Leadership Forum

2011  Student   News Entrepreneur Bootcamp   
Knight Digital Media Center, Annenberg School for Communication
USC Greif Center for Entrepreneurial Studies
University of Southern Californina  

2013  Observer         Eric Lewis, CEO
Olympic Medical Center, Port Angeles, WA

Licensure and Certification (Active)

1989  Certification in Neurology
American Board of Psychiatry and Neurology

2008  Washington State Medical License

2011  Certification in Neuro-oncology\
United Council on Neurological Subspecialties

Academic Appointments

1991-93 Instructor in Neurology    
Harvard Medical School

1994-99 Assistant Professor of Neurology  
Harvard Medical School

1999-2008 Associate Professor of Neurology 
Harvard Medical School

2010-present  Clinical Associate Professor of Neurology  
University of Washington School of Medicine

Hospital or Affiliated Institution Appointments

1991-93 Assistant in Neurology     Massachusetts General Hospital
     
1994-99 Assistant Neurologist      Massachusetts General Hospital
     
1999-03 Associate Neurologist      Massachusetts General Hospital

1998-01 Executive Director              Brain Tumor Center  Massachusetts General Hospital

2003-08 Associate Neurologist (Radiologist)  Massachusetts General Hospital

2003-08 Staff Neuroradiologist      Massachusetts General Hospital

2003-08 Neuroradiology Reviewer     Partners Tumor Imaging Metrics Core

2003-08 Director    Stephen E. and Catherine Pappas Brain Tumor Imaging Research Program

2003-08 Medical Advisor   Stephen E. and Catherine Pappas Neuro-oncology Nurse Practitioner Research Program

2005-08 Research Associate, Brain Imaging Center, McLean Hospital

2008-present   Member         Swedish Neuroscience Institute

2008-13 Director, Neurology Division, Swedish Neuroscience Institute      

2009-present   Member  Swedish Cancer Institute

2009-present  Neuroradiologist  Swedish Medical Center

2011-13 Associate Chief Medical Director   Swedish Neuroscience Institute

2011-present  Board of Directors, Swedish Neuroscience Institute Physicians Medical Group

2013  Chairman, Board of Directors, Swedish Neuroscience Institute Physicians Medical Group

2013-present  Vice President of Medical Affairs  Swedish Medical Center, Cherry Hill

Major Committee Assignments

1996-98 Subcommittee on Human Research   (Institutional Review Board)  Massachusetts General Hospital
     
1999  Residency Selection Committee   Partner's Neurology Program  MGH/Brigham and Women's

2000-01 Cancer Center Executive Committee  MGH Cancer Center

2000-01 Clinical Performance Management  Neurology Team Co-Leader    MGH Neurology Service
 
2001 Cancer Center Space Planning   Steering Committee  MGH Cancer Center
   
2001-03 Managed Care and Contracting Committee    Massachusetts General Physician’s Organization

2009-present  SNI Research Steering Committee  Swedish Neuroscience Institute

2009-present  Swedish Continuing Medical Education (CME) Committee  Swedish Medical Center
   
2010-present  Chairman, Data Safety Monitoring Board, “A Phase II study of the combination of high-dose methotrexate    and intrathecal liposomal cytarabine in patients with parenchymal and leptomeningeal metastases from breast cancer.”
University of Washington Medical Center/Fred Hutchinson Cancer Research Center

2010-present  SCI Research Steering Committee  Swedish Cancer Institute

2011-present  Cancer Committee      Swedish Cancer Institute

2012-present  Chair  NeuroNEXT Industry Outreach Committee  NINDS/NeuroNEXT

2012  Chair          Economic Disruption in Healthcare   Foster-Premera Symposium

Professional Societies

American Academy of Neurology

1986-present  Member   American Academy of Neurology

1998-present  Fellow   American Academy of Neurology
     
1998-present   Member     Section on Neuro-oncology

1998-2006   Executive Committee    Section on Neuro-oncology

1998-01 Scientific Topic Chair      Section on Neuro-oncology

2000-05 Preuss Award Subcommittee    American Academy of Neurology

2002-04   Chair    Section on Neuro-oncology

2002-present   Science Committee   American Academy of Neurology

2005-06  Director    Enhanced Vertical Integration
               Section on Neuro-oncology

2005-08 Director    Neurological Complications of Systemic Cancer, Educational Course, Annual Meeting

2005  Plenary Address   Contemporary Clinical Issues and Case Studies Plenary Session  2005 Annual Meeting

2006-present   Member  UCNS Neuro-Oncology Board Examination Committee

2007-09   Science Editor   AAN.com

2007-09   Chair    Futurist Work Group Science Committee

2007-09   Member    Boxing Task Force Science Committee

2008-09  Member    Public Relations Committee

2008  Fellow   Palatucci Advocacy Leadership Forum

2008-present   Participant      Neurology on the Hill

2008-present   Member    Brain PAC

American College of Healthcare Executives

2011-present   Member        

American Neurological Association

2007-present   Active Member

2008    Member    Abstract Review Committee

2013  Fellow

American Society of Clinical Oncology

2006-present  Member

2006  Invited Speaker   “Advanced Neuroimaging for Brain Tumors”   Meet the Professor Education Session

European Association for Neuro-oncology

1998-present  Member

Northwest Science Writers Association

2009-present  Member

2010-11  At-Large Member    Board of Trustees

2010-11  Founding Editor    NSWA ScienceWire  http://nwscience.org/sciencewire/

2011   Founder    NSWA Career Development Awards   http://nwscience.org/

2011  Chair    Awards Subcommittee

Society for Neuro-oncology

1998-present   Member

2012-present    Editorial Board   Neuro-Oncology

Washington State Medical Association

2009-present  Member

Washington State Neurological Society

2008-present  Member      
 
2009-10  Vice President/President Elect   

2010-11 President

2011-13  Immediate Past President

World Congress of Neurology

2005  Invited Speaker    Plenary Session on Neuro-oncology, Sydney, Australia

Editorial Activities

1993-present  Ad hoc reviewer       Cancer

1994-presnt  Ad hoc reviewer    Journal of Neurology and Experimental Neuropathology

1996-present  Ad hoc reviewer     Journal of Neuro-Oncology

1997-presnt  Ad hoc reviewer      New England Journal of Medicine

1998-present  Ad hoc reviewer     Journal of NeuroVirology

1999-present  Ad hoc reviewer    Journal of Clinical Oncology

2000-01 Topic editor   Current Opinion in Neurology

2003-present  Ad hoc reviewer    Journal of Neuroimaging

2005-present  Ad hoc reviewer   Journal of Clinical Microbiology

2006    Reviewer Clinical Research Infrastructure Initiative Medical Research Council, The Wellcome Trust, London, UK

2006-present  Ad hoc reviewer    Neuro-oncology

2006-present   Ad hoc reviewer    Neurology

2006-present   Ad hoc reviewer     European Journal of Neurology

2007-09  Associate Editor for Science AAN.com

2007   Advisory Board Member   Adams and Victor’s Principles of Neurology

2008-present    Editor    BrainWaves, newsletter of the Swedish Neuroscience Institute tiny.cc/snibrainwaves

2009-11 Editor      Website    Washington State Neurological Society    www.washingtonneurology.org/

2010-presnt    Founding editor    SNIblog.com    http://sniblog.com

2010-11  Member    Board of Directors     Northwest Science Writers Association

2010-11  Founding editor    NSWA ScienceWire   http://nwscience.org/sciencewire/

2011-present  Ad hoc reviewer    Neurohospitalist

2012-3   Editorial Board    Neuro-Oncology

Industry Activities

2005-present    Central Neuroradiology Review   Perceptive Informatics, Inc. and GlaxoSmithKline, PLC

2008-present  Scientific Advisor    Perceptive Informatics, Inc.

2010-present   Clinical Advisor    Neuroscience Centers of Excellence Survey    NeuStrategy, Inc.

2012-presnt    Chair     NeuroNEXT Industry Outreach Committee     NINDS/NeuroNEXT

2012-present    Founding Member, Webmaster   NeuroNeighborhood     Seattle Neurotech Cluster

Fundraising Activities

1993-2008 Director         Brain Tumor Research Fund

1999  Invited speaker       MGH Visiting Committee Lecture

1999-2008 Medical Director    Strides of Survival   Annual walk for MGH Brain Tumor Research Fund

1999-2008 Medical Co-Director    Brian D. Silber Memorial Golf Tournament
               Annual golf tournament for  MGH Spine Tumor Center
 
2001-06 Medical Director    Santa Lucia Annual Dinner for the MGH Brain Tumor Research Fund

2003   Lead solicitor      $5.7 million gift to MGH Brain Tumor Center, establishing the Stephen E.
               Pappas Center for Neuro-oncology and Stephen E. Pappas Neuroimaging Research Program,
               as well as a nursing research program and grants program

2004-06 Medical Director   DiPlacido Annual Dinner for the MGH Brain Tumor Research Fund

Awards and Honors

1985  Outstanding First Year Resident   Department of Internal Medicine   Loma Linda University Medical Center

1986 Alpha Omega Alpha    Vanderbilt University School of Medicine, Housestaff Member
    
1988  Sandoz Award, Neurology Department Vanderbilt University Medical Center

1999  Partners in Excellence Award    MGH/Partners HealthCare System

2007  Alumnus of the Year     Southern Adventist University    Collegedale, TN

Bibliography
1. Henson JW, Brace RA. An intravascular protein osmometer. Am J Physiol 1983;244:H726-9.

2. Kirshner HS, Casey PF, Henson J, Heinrich JJ. Behavioral features and lesion localization in Wernicke's aphasia.   Aphasiology 1989;3:169-176.
 
3. Henson JW, Wiley RG. CNS chloromas in patients presenting with eosinophilia. Neurology 1989;39:1386-8.

4. Henson JW, Jalaj JK, Walker RW, Stover DE, Fels AOS. Pneumocystis carinii pneumonia in patients with primary brain tumors. Arch Neurol 1991;48:406-9.

5. Szabo A, Dalmau J, Manley G, Henson J, Posner JB, Furneaux HM. HuD, a paraneoplastic encephalitis antigen contains RNA binding domains and is homologous to Elav and Sex-lethal. Cell 1991;67:325-333.

6. Henson JW, Rosenblum M, Armstrong D, Furneaux H. Amplification of JC virus DNA from brain and cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. Neurology 1991;41:1967-1971.

7. Henson JW, Cardo-Cardon C, Posner JB. P-glycoprotein expression in brain tumors.  J Neuro-Oncol 1992;14:37-43.

8. Newton H, Henson J, Walker RW. Extraneural metastases in ependymoma. J Neuro-Oncol 1992;14:135-142.

9. Henson JW, Saffer JD, Furneaux H. The transcription factor Sp1 binds to the JC virus promoter and is selectively expressed in glial cells in human brain. Ann Neurol 1992;32:72-7.

10. Henson JW. Regulation of the glial-specific JC virus early promoter by the transcription factor Sp1. J Biol Chem 1994;269:1046-1050.

11. Ueki K, Richardson EP, Henson JW, Louis DN. In situ PCR demonstration of JC virus in PML, including an index case. Ann Neurol 1994;36:670-3. 

12. Henson JW, Schnitker BL, Correa KM, vonDeimling A, Fassbender F, Xu H-J, Benedict WF, Yandell DW, Louis DN. The retinoblastoma gene is involved in malignant progression of astrocytomas. Ann Neurol 1994;36:714-721.

13. Alderson LM, Castleberg RL, Rubio MP, Schnitker BL, Louis DN, Henson JW. Human gliomas with wild-type p53 express bcl-2. Cancer Res 1995;55:999-1001.

14. Henson JW, Schnitker BL, Lee TS, McAllister J. Cell-specific activation of the glial- specific JC virus early promoter by large T antigen. J Biol Chem 1995;270:13240-5.

15. Ueke K, Henson JW, Louis DN. CKDN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely related. Cancer Res 1996;56:150-3.

16. Alderson LM, Henson JW. Regional subacute cranial neuropathies following intracarotid cisplatin. Neurology 1996;47:1088-1090.

17. Moyaeri NN, Henson JW, Schaefer PW, Zervas NT. Spinal dural enhancement associated with spontaneous intrancranial hypotension. J Neurosurg 1998;88:912-8.

18. Pomerantz HD,  Henson JW, Lessell S. Cerebral radiation blindness. American Journal of Ophthalmology 1998;126:609-611.

19. Shafqat S, Hedley-Whyte ET, Henson JW. Age-dependent rate of anaplastic progression in low-grade astrocytomas. Neurology 1999;52:867-9.

20. vanGorder MA, Della Pelle T., Henson JW, Cosimi AB, Colvin RB. Polyomavirus infection of cynomolgus monkeys in tolerance protocols receiving renal allografts of baboon xenografts. Am J Pathol 1999;154:1273-1284.

21. Henson JW, Yang J, Batchelor T. Vitreous methotrexate concentration after high-dose intravenous therapy for primary CNS lymphoma. J Clin Oncol 1999;17:1329.

22. Kennedy DN, O’Craven KM, Ticho BS, Goldstein AM, Makris N, Henson JW. Structural and functional brain asymmetries in human situs inversus. Neurology 1999;53:1260-1265.

23. Kim H-S, Goncalves N, Henson JW. Glial-specific regulation of the JC virus early promoter by large T antigen. J Virol 2000:74;755-763.

24. Henson JW, Thornton AF, Louis DN. PCV chemotherapy for spinal cord astrocytoma. Neurology 2000;54:518-520.

25. Tortosa A, Ino Y, Odell  N, Swilley S, Louis DN, Henson JW. Molecular genetics of radiographically defined de novo glioblastoma multiforme. Neuropathol App Neurobiol 2000;26: 544-552.

26. von Deimling A, Fimmers R, Schmidt MC, Bender B, Fassbender F, Nagel J, Jahnke R, Kaskel P, Duerr EM, Koopmann J, Maintz D, Steinbeck S, Wick W, Platten M, Muller DJ, Przkora R, Waha A, Blumcke B, Wellenreuther R, Meyer-Puttlitz B, Schmidt O, Mollenhauer J, Poustka A, Stangl AP, Lenartz D, von Ammon K, Henson JW, Schramm J, Louis DN, Wiestler OD. Comprehensive allelotype and genetic analysis of 466 human nervous system tumors. J Neurol Exp Neuropathol 2000;59:544-58.

27. Rabinov JD, Lee PL, Barker FG, Louis DN, Harsh IV GR, Cosgrove GR, Chiocca EA, Thornton AF, Loeffler JS, Henson JW, Gonzalez RG. In Vivo MRS at 3 Tesla Predicts Recurrent Glioma vs. Radiation Effects - Initial Experience. Radiology 2002;225:871-879.

28. Kim S-Y, Woo M-S, Kim W-K, Choi E-C, Henson JW, Kim H-S. Glial Cell-Specific Regulation of the JC Virus Early Promoter by Histone Deacetylase Inhibitors. J Virology 2003;77:3394-3401.

29. Batchelor TT, Del Checcolo G, Ciordia R, Foster C, Henson JW. High-dose intravenous methotrexate chemotherapy for intra-ocular lymphoma. Clin Cancer Res 2003;9:711-715.

30. Lev ML, Ozsunar Y, Rasheed AA, Henson JW, Barest GD, Harsh GR, Fitzek MM, Chiocca EA, Rabinov JR, Csavoy AN,  Hochberg FH, Rosen BR, Schaeffer PW, Gonzalez RG. Glial Tumor Grading and Outcome Prediction using Dynamic Spin-Echo MR Susceptibility Mapping compared to Conventional Contrast Enhanced MRI: Confounding Effect of Elevated relative Cerebral Blood Volume of Oligodendrogliomas. Am J Neuroradiol 2004;25:214-21.

31. Henson JW, Nogueira, RG, Covarrubias DJ, Gonzalez RG, Lev M. Gadolinium Contrast CT Angiography of the Circle of Willis and Neck. Am J Neuroradiol. Am J Neuroradiol 2004;25:969-972.

32. Kim SK, Choi E-C, Henson JW, Kim H-S. Transcriptional Activation Of JC Virus Early Promoter By Phorbol Ester And Interlukin-1: Critical Role Of Nuclear Factor-1. Virology 2004;327:60-69.

33. Gaviani P, Gonzalez RG, Zhu J-J, Batchelor TT, Henson JW. Central Neurogenic Hyperventilation in Brainstem Glioma: Elevation of Tumor and CSF Lactate as Detected by MRS. Neurology 2005;64:166-167.

34. Gaviani P,  Schwartz RB, Hedley-Whyte E, Ligon KL, Robicsek A, Schaefer P, Henson JW. Diffusion weighted imaging of fungal cerebral infection in immunocompromised patients. AJNR Am J Neuroradiol 2005;26:1115-1121.

35. Henson JW, Hobbs W, Chakravarti A, Louis DN. Alterations in p53, p21, and MIB-1 labeling index in primary human astrocytomas following radiation therapy. J Neuro-oncol 2005;74:151-154.

36. Mavrakis AN, Halpern EF, Barker FG, Gonzalez RG. Henson JW. Optimization of Biopsy Site Selection in the Diagnostic Evaluation of Patients with a Newly Detected Brain Mass. Neurology 2005;65:908-911.

37. Aghi M, Gaviani P, Henson JW, Batchelor TT, Louis DN, Barker FG. Magnetic resonance imaging characteristics predict EGFR amplification status in glioblastoma. Clin Cancer Res 2005;11:8600-8605.

38. Gavini P, Mullins ME, Braga TA, Hedley-Whyte ET, Halpern EF, Schaefer PS, Henson JW. Improved detection of metastatic melanoma by T2*-weighted imaging. AJNR Am J Neuroradiol 2006;27:605-608.

39. Kim SY, Kim DH, Hyun JW, Henson JW, Kim HS. Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun 2006;344:3-8

40. Noronha V, Berliner N, Ballen KK, Lacy J, Kracher J, Baehring J, Henson JW. Treatment-related myelodysplasia/AML in a patient with a history of breast cancer and an oligodendroglioma treated with temozolomide: case report and review of the literature. Neuro-oncology 2006;8:280-283.

41. Chou RC, Henson JW, Tian  D, Hedley-Whyte ET, Reginato AM. Successful Treatment of Rheumatoid Meningitis with Cyclophosphamide but not Infliximab. Ann Rheum Dis 2006;65(8):1114-1116.

42. Ulmer S, Braga TA, Barker II FG, Lev M, Gonzalez RG, Henson JW. Clinical and radiographic features of peritumoral infarction following resection of malignant gliomas. Neurology 2006;67:1668-1670.

43. Nemeth AJ, Henson JW, Mullins ME, Schaefer PW. Improved detection of skull metastasis with diffusion-weighted imaging. AJNR Am J Neuroradiol. 2007;28(6):1088-92.

44. Krejcarek SC, Grant PE, Henson JW, Tarbell NJ, Yock, TI. Physiologic and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation.  Int J Radiat Oncol Biol Phys. 2007;68(3):646-9.

45. Eichler AF, Batchelor TT, Henson JW. Diffusion and perfusion imaging in subacute neurotoxicity following high-dose intravenous methotrexate. Neuro-oncology 2007;9:373-377.

46. Henson JW, Cascino GD, Post ME. International Science at the Annual Meeting of the American Academy of Neurology. Neurology 2007 69:1712-1714.

47. Farrell CJ, Hoh BL, Pisculli ML, Henson JW, Barker FG, Curry WT. Limitations of diffusion-weighted imaging in the diagnosis of postoperative infections. Neurosurgery 2008 62:577-583.

48. Lin NU, Carey LA, Liu MC, Younger J, Come SE, Ewend M, Harris G, Bullitt E, van den Abbeele A, Henson JW, Li X, Gelman R, Burstein HJ, Kasparian E, Crawford A, Kirsch DG, Hochberg F, Winer E. Phase 2 Trial of Lapatinib for Brain Metastases in Patients with HER2-Positive Breast Cancer. J Clin Oncol 2008 26:1993-1999.

49. Eichler AF, Kuter I, Ryan P, Schapira L, Younger J, Henson JW. Survival after diagnosis of brain metastasis in breast cancer: Importance of Her2 status. Cancer 2008 112:2359-2367.

50. Sher DJ, Henson JW, Avutu B, Hochberg F, Batchelor T, Martuza R, Barker F, Loeffler JS, Chakravarti A. The Added Value of Concurrently-Administered Temozolomide Versus Adjuvant Temozolomide Alone in Newly-Diagnosed Glioblastoma. Neuro-oncology 88:43-50.

51. Kesari S, Schiff D, Henson JW, Muzikansky A, Gigas DC, Doherty L, Batchelor TT, Longtine JA, Ligon KL, Weaver S, Laforme A, Ramakrishna N, Black PM, Drappatz J, Ciampa A, Folkman J, Kieran M, Wen PY. Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro Oncol 2008 10:300-308.

52. Wei SC, Ulmer S, Lev MH, Pomerantz SR, Gonzalez RG, Henson JW.  Value of coronal reformations in CT evaluation of acute head trauma. Am J Neuroradiol 2010 31:334-339.

53. Jung AK, Henson JW, Susanto D, Caylor LM, Doherty MJ. Holohemispheric developmental venous anomaly. Neurology (in press)

54. Shaw T, Lev MH, McGowan J. Henson JW. Mohawk Hematoma: Subgaleal Decompression of a Vertex Venous Epidural Hemorrhage. (submitted)

55. Ulmer S, Barker FG, Henson JW. Multifocality in newly diagnosed malignant glioma. (in preparation)

Book Chapters and Reviews

56. Henson JW, Jalaj JK, Walker RW, Stover DE, Fels AOS. Pneumocystis carinii pneumonia in patients with primary brain tumors. Clinical Digest Series. 1992.

57. Henson JW, Posner JB. Neurological complications of cancer and its treatment. In: Holland J, Frei E, eds. Cancer Medicine. 3rd ed., 1993. Malvern, Pennsylvania: Lea and Febiger.

58. Henson JW, Ferraro MJ. Case records of the Massachusetts General Hospital. N Engl J Med1993;329:1335-1341.

59. Henson JW. Neurological complications of malignant melanoma and other cutaneous  malignancies. In Wiley R., ed. Neurological Complications of Cancer. New York: Marcel Dekker, 1995.

60. Alderson LM, Henson JW. Neurological complications of breast cancer. In Samuels M., ed. Office Practice of Neurology, 1996. New York: Churchill Livingstone.

61. Henson JW. Coupling JC virus transcription and replication. J NeuroVirology 1996;2:57-59.

62. Henson JW. Promoters for the expression of gene products in neurons and glia. In Chiocca EA, Breakefield XO, eds. Gene Transfer and Therapy for Neurological Diseases, 1998.

63. Cher L, Henson JW, Hochberg FH. Paraneoplastic neurological syndromes. In Vinken PJ, and Bruyn GW, ed. Handbook of Clinical Neurology Vol. 27 (71): Systemic Diseases Part III Chap 27, M.J. Aminoff and C.G. Goetz, series editors, 1998 Elsevier Science B.V.

64. Avgeropoulos N, Henson JW. Primary meningeal sarcomas. In Johnson D, et al. eds. Textbook of Uncommon Cancer 1999.

65. Henson JW. Glioblastoma, anaplastic astrocytoma, and anaplastic oligodendroglioma. A patient guide. MGH Brain Tumor Center, 1999.

66. Henson JW. A guide to chemotherapy for patients with high-grade gliomas. MGH Brain Tumor Center, 1999.

67. Henson JW, Louis DN. Edward Pierson Richardson Jr., M.D. and the discovery of PML. J Neurovirol 1999:5;325-326.

68. Henson JW. Early genetic events in the formation of astrocytomas. In Curr Opin Neurol 2000;13:613-617. Henson JW, ed.

69. Sharis C, Henson JW. Neurological complications of radiation therapy. Up-to-Date. 2001.

70. Kim H-S, Henson JW, Frisque RJ. Transcription and replication in the human polyomaviruses. In Human Polyomaviruses: Molecular and Clinical Perspectives. Khalili K,  and Stoner GL, eds. 2001.

71. Henson JW. Spinal cord gliomas. In Curr Opin Neurol 2001;14:679-682. Henson JW, ed.

72. Jeyapalan S, Henson JW. Neurologic Complications of Lung Cancer. In Wen P, Schiff D, eds., Neurological Complications of Cancer, 2002.

73. Henson JW, Batchelor TT. Intra-ocular lymphoma. In Primary Central Nervous System Lymphoma. Batchelor TT, ed. 2004.

74. Henson JW, Gonzalez RG. Imaging of nervous system tumors. In: Neurology in Clinical Practice. Bradley WG, Daroff RB, Fenichel GM, Jankvic J, eds. 2004.

75. Henson JW. Update on primary brain tumors: Imaging. American Society of Clinical Oncology. Syllabus, Educational Program. 2004. pp 116-119.

76. Henson JW, Gonzalez RG. Neuroimaging of glioma therapy. Expert Review of Neurotherapeutics. 2004; 4:665-671.

77. Henson JW, Gonzalez RG. Imaging. In: Cancer of the Nervous System. Loeffler J, and Black PM, eds. 2004.

78. Henson JW, Gaviani P, Gonzalez RG. Magnetic resonance imaging in the therapy of adult gliomas. Lancet Oncology 2005;6:167-175.

79. Korf BR, Henson JW, Stemmer-Rachimimov A. Case records of the Massachusetts General Hospital. N Engl J Med 2005;352:1800-1808.

80. Henson JW. Treatment of Glioblastoma multiforme: A new standard. Arch Neurol 2006;63:337-341.

81. Henson JW, Ackerman RA, Barker II FG. Comment on Petrik V et al. Godfrey Hounsfield and the dawn of computed tomography. Neurosurgery 2006;58:787.

82. Cole AJ, Henson JW, Roehrl MHA, Frosch MP. Case 24-2007: A 20-Year-Old Pregnant Woman with 5 Altered Mental Status. New Engl J Med 2007;357:589-600.

83. Ulmer S, Harris G, Henson JW. Neuroimaging issues in assessing response to brain tumor therapy. In Newton HB and Jolesz FA. Handbook of neuro-oncology neuro-imaging. Elsevier 2007.

84. Vossough A, Gonzalez RG, Henson JW, Schaefer PW. Brain metastasis. In Newton HB and Jolesz FA. Handbook of neuro-oncology neuro-imaging. Elsevier 2007.

85. Henson JW, Avitzur O. The online neurologist Nat Clin Pract Neurol. 2007 3:589.

86. Vossough A, Gonzalez RG, Henson JW. Imaging neurologic manifestations of oncologic disease. In Schiff D, Kesari S, and Wen PY. Cancer Neurology in Clinical Practice. Humana Press 2008.

87. Henson JW, Ulmer S, Harris GJ. Brain Tumor Imaging in Clinical Trials. AJNR 2008 29:419-424.

88. Henson JW. Neurology patients online: perceptions and reality. Nat Clin Pract Neurol 2008 4:347.

89. Pruitt A, Henson JW. Equal care for the elderly with low-grade gliomas? Neurology 2009 73:2056-2057.

90. Henson JW, Jung LK. Neurology on the Internet. In Avitzur O, Neurol Clin 2010 28:385-393.

91. Henson JW, Keogh BP. Plasticity: Teaching an old brain new tricks. Neurology 2010 74:53-55.

92. Mrugala M, and Henson JW. Neurological complications of malignant melanoma. In Newton H and Malkin M, Neurologic Complications of Systemic Cancer. Taylor and Francis, 2010

93. Grossheim L, Malkin M, Jayapalan S, Henson JW. Neurologic complications of lung cancer. In Newton H and Malkin M, Neurologic Complications of Systemic Cancer. Taylor and Francis, 2010.

94. Henson JW, Keogh B. Assessing radiographic response to bevacizumab in patients with GBM. In Chamberlain M, Controversies in Neuro-oncology 2010 1:94-99. Bentham Books.

95. Henson JW, Wulff, J. Inpatient Management of Neuro-oncology Patients. In Josephson, Freeman and Likosky, Neurohospitalist Medicine, Cambridge University Press, Cambridge, UK 2011

96. Henson JW, Gonzalez, RG. Neuroimaging. In Grisold W and Soffietti R, Neuro-oncology, Handbook of Clinical Neurology 2012 104:110-126.

97. Keogh BP, Henson JW. Clinical Manifestations and Diagnostic Imaging of Brain Tumors. In Lacy J and Baehring J. An Update on Neuro-Oncology. Hematology/Oncology Clinics of North America (submitted).

Philosophy of Care

To provide the best care for patients with brain and spinal cord tumors.

Personal Interests

Biking, boating

Medical School

Loma Linda University School of Medicine

Residency

Vanderbilt University Medical Center

Fellowship(s)

Memorial Sloan-Kettering Cancer Center

Board Certifications

American Board of Psychiatry and Neurology, Neurology, 1989

Languages:

English

Professional Associations:

American Academy of Neurology, American Neurological Association, Society for Neuro-Oncology, Washington State Neurological Society, American College of Healthcare Executives

Additional Information:

Curriculum Vitae


John William Henson IV, MD, MBA, FAAN, FANA
      
Vice President of Medical Affairs
Swedish Medical Center, Cherry Hill campus
Neuro-oncologist
Neuroradiologist
Swedish Medical Center

Administrative Address -  Swedish Medical Center, Cherry Hill
500 17th Avenue, Professional Building, Suite 402
Seattle, WA 98122
Telephone: 206-320-2057
Fax: 206-320-3153
    
Clinical Address - Ivy Center for Advanced Brain Tumor Treatment
550 17th Avenue, Suite 540
Seattle, WA 98122
Telephone: 206-320-2300

Place and Date of Birth  Chattanooga, Tennessee
January 3, 1958

Education  

1980  BA   Southern Adventist University, Collegedale, TN

1984  MD    Loma Linda University School of Medicine, Loma Linda, CA

2013  MBA  University of Washington Foster School of Business

Postdoctoral Training

1984-85 Intern    
Internal Medicine   Loma Linda University Medical Center

1985-88 Resident   
Neurology    Vanderbilt University Medical Center

1987-88 Chief Resident 
Neurology    Vanderbilt University Medical Center

1988-91 Fellow   
Neuro-oncology  Memorial Sloan-Kettering Cancer Center 

1990-91 Clinical Scholars 
Neuro-oncology  Biomedical Research Training Program
Fellow Memorial Sloan-Kettering Cancer Center/NCI

1990  Summer Student Neurobiology  
Cold Spring Harbor Laboratory
Program in  Neurobiology

1999  Student  
Managing Technical Sloan School of Management 
Professionals and  Executive Program
Massachusetts Institute of Technology

1999  Student  
IT for the non-IT Executive
Sloan School of Management Executive
Program, Massachusetts Institute of Technology

2000  Student  
Enhancing Executive Influence 
John F. Kennedy School of Government
Harvard University

2000  Student   Leadership Development for Physicians in Academic Health Centers
Harvard School of Public Health
Harvard University

2001  Student  Primer: Philanthropy 
New England Association for Healthcare Philanthropy

2001-03 Fellow  Diagnostic  Neuroradiology 
Massachusetts General Hospital, Division of Neuroradiology

2008  Fellow  Palatucci Advocacy Leadership Forum

2011  Student   News Entrepreneur Bootcamp   
Knight Digital Media Center, Annenberg School for Communication
USC Greif Center for Entrepreneurial Studies
University of Southern Californina  

2013  Observer         Eric Lewis, CEO
Olympic Medical Center, Port Angeles, WA

Licensure and Certification (Active)

1989  Certification in Neurology
American Board of Psychiatry and Neurology

2008  Washington State Medical License

2011  Certification in Neuro-oncology\
United Council on Neurological Subspecialties

Academic Appointments

1991-93 Instructor in Neurology    
Harvard Medical School

1994-99 Assistant Professor of Neurology  
Harvard Medical School

1999-2008 Associate Professor of Neurology 
Harvard Medical School

2010-present  Clinical Associate Professor of Neurology  
University of Washington School of Medicine

Hospital or Affiliated Institution Appointments

1991-93 Assistant in Neurology     Massachusetts General Hospital
     
1994-99 Assistant Neurologist      Massachusetts General Hospital
     
1999-03 Associate Neurologist      Massachusetts General Hospital

1998-01 Executive Director              Brain Tumor Center  Massachusetts General Hospital

2003-08 Associate Neurologist (Radiologist)  Massachusetts General Hospital

2003-08 Staff Neuroradiologist      Massachusetts General Hospital

2003-08 Neuroradiology Reviewer     Partners Tumor Imaging Metrics Core

2003-08 Director    Stephen E. and Catherine Pappas Brain Tumor Imaging Research Program

2003-08 Medical Advisor   Stephen E. and Catherine Pappas Neuro-oncology Nurse Practitioner Research Program

2005-08 Research Associate, Brain Imaging Center, McLean Hospital

2008-present   Member         Swedish Neuroscience Institute

2008-13 Director, Neurology Division, Swedish Neuroscience Institute      

2009-present   Member  Swedish Cancer Institute

2009-present  Neuroradiologist  Swedish Medical Center

2011-13 Associate Chief Medical Director   Swedish Neuroscience Institute

2011-present  Board of Directors, Swedish Neuroscience Institute Physicians Medical Group

2013  Chairman, Board of Directors, Swedish Neuroscience Institute Physicians Medical Group

2013-present  Vice President of Medical Affairs  Swedish Medical Center, Cherry Hill

Major Committee Assignments

1996-98 Subcommittee on Human Research   (Institutional Review Board)  Massachusetts General Hospital
     
1999  Residency Selection Committee   Partner's Neurology Program  MGH/Brigham and Women's

2000-01 Cancer Center Executive Committee  MGH Cancer Center

2000-01 Clinical Performance Management  Neurology Team Co-Leader    MGH Neurology Service
 
2001 Cancer Center Space Planning   Steering Committee  MGH Cancer Center
   
2001-03 Managed Care and Contracting Committee    Massachusetts General Physician’s Organization

2009-present  SNI Research Steering Committee  Swedish Neuroscience Institute

2009-present  Swedish Continuing Medical Education (CME) Committee  Swedish Medical Center
   
2010-present  Chairman, Data Safety Monitoring Board, “A Phase II study of the combination of high-dose methotrexate    and intrathecal liposomal cytarabine in patients with parenchymal and leptomeningeal metastases from breast cancer.”
University of Washington Medical Center/Fred Hutchinson Cancer Research Center

2010-present  SCI Research Steering Committee  Swedish Cancer Institute

2011-present  Cancer Committee      Swedish Cancer Institute

2012-present  Chair  NeuroNEXT Industry Outreach Committee  NINDS/NeuroNEXT

2012  Chair          Economic Disruption in Healthcare   Foster-Premera Symposium

Professional Societies

American Academy of Neurology

1986-present  Member   American Academy of Neurology

1998-present  Fellow   American Academy of Neurology
     
1998-present   Member     Section on Neuro-oncology

1998-2006   Executive Committee    Section on Neuro-oncology

1998-01 Scientific Topic Chair      Section on Neuro-oncology

2000-05 Preuss Award Subcommittee    American Academy of Neurology

2002-04   Chair    Section on Neuro-oncology

2002-present   Science Committee   American Academy of Neurology

2005-06  Director    Enhanced Vertical Integration
               Section on Neuro-oncology

2005-08 Director    Neurological Complications of Systemic Cancer, Educational Course, Annual Meeting

2005  Plenary Address   Contemporary Clinical Issues and Case Studies Plenary Session  2005 Annual Meeting

2006-present   Member  UCNS Neuro-Oncology Board Examination Committee

2007-09   Science Editor   AAN.com

2007-09   Chair    Futurist Work Group Science Committee

2007-09   Member    Boxing Task Force Science Committee

2008-09  Member    Public Relations Committee

2008  Fellow   Palatucci Advocacy Leadership Forum

2008-present   Participant      Neurology on the Hill

2008-present   Member    Brain PAC

American College of Healthcare Executives

2011-present   Member        

American Neurological Association

2007-present   Active Member

2008    Member    Abstract Review Committee

2013  Fellow

American Society of Clinical Oncology

2006-present  Member

2006  Invited Speaker   “Advanced Neuroimaging for Brain Tumors”   Meet the Professor Education Session

European Association for Neuro-oncology

1998-present  Member

Northwest Science Writers Association

2009-present  Member

2010-11  At-Large Member    Board of Trustees

2010-11  Founding Editor    NSWA ScienceWire  http://nwscience.org/sciencewire/

2011   Founder    NSWA Career Development Awards   http://nwscience.org/

2011  Chair    Awards Subcommittee

Society for Neuro-oncology

1998-present   Member

2012-present    Editorial Board   Neuro-Oncology

Washington State Medical Association

2009-present  Member

Washington State Neurological Society

2008-present  Member      
 
2009-10  Vice President/President Elect   

2010-11 President

2011-13  Immediate Past President

World Congress of Neurology

2005  Invited Speaker    Plenary Session on Neuro-oncology, Sydney, Australia

Editorial Activities

1993-present  Ad hoc reviewer       Cancer

1994-presnt  Ad hoc reviewer    Journal of Neurology and Experimental Neuropathology

1996-present  Ad hoc reviewer     Journal of Neuro-Oncology

1997-presnt  Ad hoc reviewer      New England Journal of Medicine

1998-present  Ad hoc reviewer     Journal of NeuroVirology

1999-present  Ad hoc reviewer    Journal of Clinical Oncology

2000-01 Topic editor   Current Opinion in Neurology

2003-present  Ad hoc reviewer    Journal of Neuroimaging

2005-present  Ad hoc reviewer   Journal of Clinical Microbiology

2006    Reviewer Clinical Research Infrastructure Initiative Medical Research Council, The Wellcome Trust, London, UK

2006-present  Ad hoc reviewer    Neuro-oncology

2006-present   Ad hoc reviewer    Neurology

2006-present   Ad hoc reviewer     European Journal of Neurology

2007-09  Associate Editor for Science AAN.com

2007   Advisory Board Member   Adams and Victor’s Principles of Neurology

2008-present    Editor    BrainWaves, newsletter of the Swedish Neuroscience Institute tiny.cc/snibrainwaves

2009-11 Editor      Website    Washington State Neurological Society    www.washingtonneurology.org/

2010-presnt    Founding editor    SNIblog.com    http://sniblog.com

2010-11  Member    Board of Directors     Northwest Science Writers Association

2010-11  Founding editor    NSWA ScienceWire   http://nwscience.org/sciencewire/

2011-present  Ad hoc reviewer    Neurohospitalist

2012-3   Editorial Board    Neuro-Oncology

Industry Activities

2005-present    Central Neuroradiology Review   Perceptive Informatics, Inc. and GlaxoSmithKline, PLC

2008-present  Scientific Advisor    Perceptive Informatics, Inc.

2010-present   Clinical Advisor    Neuroscience Centers of Excellence Survey    NeuStrategy, Inc.

2012-presnt    Chair     NeuroNEXT Industry Outreach Committee     NINDS/NeuroNEXT

2012-present    Founding Member, Webmaster   NeuroNeighborhood     Seattle Neurotech Cluster

Fundraising Activities

1993-2008 Director         Brain Tumor Research Fund

1999  Invited speaker       MGH Visiting Committee Lecture

1999-2008 Medical Director    Strides of Survival   Annual walk for MGH Brain Tumor Research Fund

1999-2008 Medical Co-Director    Brian D. Silber Memorial Golf Tournament
               Annual golf tournament for  MGH Spine Tumor Center
 
2001-06 Medical Director    Santa Lucia Annual Dinner for the MGH Brain Tumor Research Fund

2003   Lead solicitor      $5.7 million gift to MGH Brain Tumor Center, establishing the Stephen E.
               Pappas Center for Neuro-oncology and Stephen E. Pappas Neuroimaging Research Program,
               as well as a nursing research program and grants program

2004-06 Medical Director   DiPlacido Annual Dinner for the MGH Brain Tumor Research Fund

Awards and Honors

1985  Outstanding First Year Resident   Department of Internal Medicine   Loma Linda University Medical Center

1986 Alpha Omega Alpha    Vanderbilt University School of Medicine, Housestaff Member
    
1988  Sandoz Award, Neurology Department Vanderbilt University Medical Center

1999  Partners in Excellence Award    MGH/Partners HealthCare System

2007  Alumnus of the Year     Southern Adventist University    Collegedale, TN

Bibliography
1. Henson JW, Brace RA. An intravascular protein osmometer. Am J Physiol 1983;244:H726-9.

2. Kirshner HS, Casey PF, Henson J, Heinrich JJ. Behavioral features and lesion localization in Wernicke's aphasia.   Aphasiology 1989;3:169-176.
 
3. Henson JW, Wiley RG. CNS chloromas in patients presenting with eosinophilia. Neurology 1989;39:1386-8.

4. Henson JW, Jalaj JK, Walker RW, Stover DE, Fels AOS. Pneumocystis carinii pneumonia in patients with primary brain tumors. Arch Neurol 1991;48:406-9.

5. Szabo A, Dalmau J, Manley G, Henson J, Posner JB, Furneaux HM. HuD, a paraneoplastic encephalitis antigen contains RNA binding domains and is homologous to Elav and Sex-lethal. Cell 1991;67:325-333.

6. Henson JW, Rosenblum M, Armstrong D, Furneaux H. Amplification of JC virus DNA from brain and cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy. Neurology 1991;41:1967-1971.

7. Henson JW, Cardo-Cardon C, Posner JB. P-glycoprotein expression in brain tumors.  J Neuro-Oncol 1992;14:37-43.

8. Newton H, Henson J, Walker RW. Extraneural metastases in ependymoma. J Neuro-Oncol 1992;14:135-142.

9. Henson JW, Saffer JD, Furneaux H. The transcription factor Sp1 binds to the JC virus promoter and is selectively expressed in glial cells in human brain. Ann Neurol 1992;32:72-7.

10. Henson JW. Regulation of the glial-specific JC virus early promoter by the transcription factor Sp1. J Biol Chem 1994;269:1046-1050.

11. Ueki K, Richardson EP, Henson JW, Louis DN. In situ PCR demonstration of JC virus in PML, including an index case. Ann Neurol 1994;36:670-3. 

12. Henson JW, Schnitker BL, Correa KM, vonDeimling A, Fassbender F, Xu H-J, Benedict WF, Yandell DW, Louis DN. The retinoblastoma gene is involved in malignant progression of astrocytomas. Ann Neurol 1994;36:714-721.

13. Alderson LM, Castleberg RL, Rubio MP, Schnitker BL, Louis DN, Henson JW. Human gliomas with wild-type p53 express bcl-2. Cancer Res 1995;55:999-1001.

14. Henson JW, Schnitker BL, Lee TS, McAllister J. Cell-specific activation of the glial- specific JC virus early promoter by large T antigen. J Biol Chem 1995;270:13240-5.

15. Ueke K, Henson JW, Louis DN. CKDN2/p16 or RB alterations occur in the majority of glioblastomas and are inversely related. Cancer Res 1996;56:150-3.

16. Alderson LM, Henson JW. Regional subacute cranial neuropathies following intracarotid cisplatin. Neurology 1996;47:1088-1090.

17. Moyaeri NN, Henson JW, Schaefer PW, Zervas NT. Spinal dural enhancement associated with spontaneous intrancranial hypotension. J Neurosurg 1998;88:912-8.

18. Pomerantz HD,  Henson JW, Lessell S. Cerebral radiation blindness. American Journal of Ophthalmology 1998;126:609-611.

19. Shafqat S, Hedley-Whyte ET, Henson JW. Age-dependent rate of anaplastic progression in low-grade astrocytomas. Neurology 1999;52:867-9.

20. vanGorder MA, Della Pelle T., Henson JW, Cosimi AB, Colvin RB. Polyomavirus infection of cynomolgus monkeys in tolerance protocols receiving renal allografts of baboon xenografts. Am J Pathol 1999;154:1273-1284.

21. Henson JW, Yang J, Batchelor T. Vitreous methotrexate concentration after high-dose intravenous therapy for primary CNS lymphoma. J Clin Oncol 1999;17:1329.

22. Kennedy DN, O’Craven KM, Ticho BS, Goldstein AM, Makris N, Henson JW. Structural and functional brain asymmetries in human situs inversus. Neurology 1999;53:1260-1265.

23. Kim H-S, Goncalves N, Henson JW. Glial-specific regulation of the JC virus early promoter by large T antigen. J Virol 2000:74;755-763.

24. Henson JW, Thornton AF, Louis DN. PCV chemotherapy for spinal cord astrocytoma. Neurology 2000;54:518-520.

25. Tortosa A, Ino Y, Odell  N, Swilley S, Louis DN, Henson JW. Molecular genetics of radiographically defined de novo glioblastoma multiforme. Neuropathol App Neurobiol 2000;26: 544-552.

26. von Deimling A, Fimmers R, Schmidt MC, Bender B, Fassbender F, Nagel J, Jahnke R, Kaskel P, Duerr EM, Koopmann J, Maintz D, Steinbeck S, Wick W, Platten M, Muller DJ, Przkora R, Waha A, Blumcke B, Wellenreuther R, Meyer-Puttlitz B, Schmidt O, Mollenhauer J, Poustka A, Stangl AP, Lenartz D, von Ammon K, Henson JW, Schramm J, Louis DN, Wiestler OD. Comprehensive allelotype and genetic analysis of 466 human nervous system tumors. J Neurol Exp Neuropathol 2000;59:544-58.

27. Rabinov JD, Lee PL, Barker FG, Louis DN, Harsh IV GR, Cosgrove GR, Chiocca EA, Thornton AF, Loeffler JS, Henson JW, Gonzalez RG. In Vivo MRS at 3 Tesla Predicts Recurrent Glioma vs. Radiation Effects - Initial Experience. Radiology 2002;225:871-879.

28. Kim S-Y, Woo M-S, Kim W-K, Choi E-C, Henson JW, Kim H-S. Glial Cell-Specific Regulation of the JC Virus Early Promoter by Histone Deacetylase Inhibitors. J Virology 2003;77:3394-3401.

29. Batchelor TT, Del Checcolo G, Ciordia R, Foster C, Henson JW. High-dose intravenous methotrexate chemotherapy for intra-ocular lymphoma. Clin Cancer Res 2003;9:711-715.

30. Lev ML, Ozsunar Y, Rasheed AA, Henson JW, Barest GD, Harsh GR, Fitzek MM, Chiocca EA, Rabinov JR, Csavoy AN,  Hochberg FH, Rosen BR, Schaeffer PW, Gonzalez RG. Glial Tumor Grading and Outcome Prediction using Dynamic Spin-Echo MR Susceptibility Mapping compared to Conventional Contrast Enhanced MRI: Confounding Effect of Elevated relative Cerebral Blood Volume of Oligodendrogliomas. Am J Neuroradiol 2004;25:214-21.

31. Henson JW, Nogueira, RG, Covarrubias DJ, Gonzalez RG, Lev M. Gadolinium Contrast CT Angiography of the Circle of Willis and Neck. Am J Neuroradiol. Am J Neuroradiol 2004;25:969-972.

32. Kim SK, Choi E-C, Henson JW, Kim H-S. Transcriptional Activation Of JC Virus Early Promoter By Phorbol Ester And Interlukin-1: Critical Role Of Nuclear Factor-1. Virology 2004;327:60-69.

33. Gaviani P, Gonzalez RG, Zhu J-J, Batchelor TT, Henson JW. Central Neurogenic Hyperventilation in Brainstem Glioma: Elevation of Tumor and CSF Lactate as Detected by MRS. Neurology 2005;64:166-167.

34. Gaviani P,  Schwartz RB, Hedley-Whyte E, Ligon KL, Robicsek A, Schaefer P, Henson JW. Diffusion weighted imaging of fungal cerebral infection in immunocompromised patients. AJNR Am J Neuroradiol 2005;26:1115-1121.

35. Henson JW, Hobbs W, Chakravarti A, Louis DN. Alterations in p53, p21, and MIB-1 labeling index in primary human astrocytomas following radiation therapy. J Neuro-oncol 2005;74:151-154.

36. Mavrakis AN, Halpern EF, Barker FG, Gonzalez RG. Henson JW. Optimization of Biopsy Site Selection in the Diagnostic Evaluation of Patients with a Newly Detected Brain Mass. Neurology 2005;65:908-911.

37. Aghi M, Gaviani P, Henson JW, Batchelor TT, Louis DN, Barker FG. Magnetic resonance imaging characteristics predict EGFR amplification status in glioblastoma. Clin Cancer Res 2005;11:8600-8605.

38. Gavini P, Mullins ME, Braga TA, Hedley-Whyte ET, Halpern EF, Schaefer PS, Henson JW. Improved detection of metastatic melanoma by T2*-weighted imaging. AJNR Am J Neuroradiol 2006;27:605-608.

39. Kim SY, Kim DH, Hyun JW, Henson JW, Kim HS. Irisolidone, an isoflavone metabolite, represses JC virus gene expression via inhibition of Sp1 binding in human glial cells. Biochem Biophys Res Commun 2006;344:3-8

40. Noronha V, Berliner N, Ballen KK, Lacy J, Kracher J, Baehring J, Henson JW. Treatment-related myelodysplasia/AML in a patient with a history of breast cancer and an oligodendroglioma treated with temozolomide: case report and review of the literature. Neuro-oncology 2006;8:280-283.

41. Chou RC, Henson JW, Tian  D, Hedley-Whyte ET, Reginato AM. Successful Treatment of Rheumatoid Meningitis with Cyclophosphamide but not Infliximab. Ann Rheum Dis 2006;65(8):1114-1116.

42. Ulmer S, Braga TA, Barker II FG, Lev M, Gonzalez RG, Henson JW. Clinical and radiographic features of peritumoral infarction following resection of malignant gliomas. Neurology 2006;67:1668-1670.

43. Nemeth AJ, Henson JW, Mullins ME, Schaefer PW. Improved detection of skull metastasis with diffusion-weighted imaging. AJNR Am J Neuroradiol. 2007;28(6):1088-92.

44. Krejcarek SC, Grant PE, Henson JW, Tarbell NJ, Yock, TI. Physiologic and radiographic evidence of the distal edge of the proton beam in craniospinal irradiation.  Int J Radiat Oncol Biol Phys. 2007;68(3):646-9.

45. Eichler AF, Batchelor TT, Henson JW. Diffusion and perfusion imaging in subacute neurotoxicity following high-dose intravenous methotrexate. Neuro-oncology 2007;9:373-377.

46. Henson JW, Cascino GD, Post ME. International Science at the Annual Meeting of the American Academy of Neurology. Neurology 2007 69:1712-1714.

47. Farrell CJ, Hoh BL, Pisculli ML, Henson JW, Barker FG, Curry WT. Limitations of diffusion-weighted imaging in the diagnosis of postoperative infections. Neurosurgery 2008 62:577-583.

48. Lin NU, Carey LA, Liu MC, Younger J, Come SE, Ewend M, Harris G, Bullitt E, van den Abbeele A, Henson JW, Li X, Gelman R, Burstein HJ, Kasparian E, Crawford A, Kirsch DG, Hochberg F, Winer E. Phase 2 Trial of Lapatinib for Brain Metastases in Patients with HER2-Positive Breast Cancer. J Clin Oncol 2008 26:1993-1999.

49. Eichler AF, Kuter I, Ryan P, Schapira L, Younger J, Henson JW. Survival after diagnosis of brain metastasis in breast cancer: Importance of Her2 status. Cancer 2008 112:2359-2367.

50. Sher DJ, Henson JW, Avutu B, Hochberg F, Batchelor T, Martuza R, Barker F, Loeffler JS, Chakravarti A. The Added Value of Concurrently-Administered Temozolomide Versus Adjuvant Temozolomide Alone in Newly-Diagnosed Glioblastoma. Neuro-oncology 88:43-50.

51. Kesari S, Schiff D, Henson JW, Muzikansky A, Gigas DC, Doherty L, Batchelor TT, Longtine JA, Ligon KL, Weaver S, Laforme A, Ramakrishna N, Black PM, Drappatz J, Ciampa A, Folkman J, Kieran M, Wen PY. Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults. Neuro Oncol 2008 10:300-308.

52. Wei SC, Ulmer S, Lev MH, Pomerantz SR, Gonzalez RG, Henson JW.  Value of coronal reformations in CT evaluation of acute head trauma. Am J Neuroradiol 2010 31:334-339.

53. Jung AK, Henson JW, Susanto D, Caylor LM, Doherty MJ. Holohemispheric developmental venous anomaly. Neurology (in press)

54. Shaw T, Lev MH, McGowan J. Henson JW. Mohawk Hematoma: Subgaleal Decompression of a Vertex Venous Epidural Hemorrhage. (submitted)

55. Ulmer S, Barker FG, Henson JW. Multifocality in newly diagnosed malignant glioma. (in preparation)

Book Chapters and Reviews

56. Henson JW, Jalaj JK, Walker RW, Stover DE, Fels AOS. Pneumocystis carinii pneumonia in patients with primary brain tumors. Clinical Digest Series. 1992.

57. Henson JW, Posner JB. Neurological complications of cancer and its treatment. In: Holland J, Frei E, eds. Cancer Medicine. 3rd ed., 1993. Malvern, Pennsylvania: Lea and Febiger.

58. Henson JW, Ferraro MJ. Case records of the Massachusetts General Hospital. N Engl J Med1993;329:1335-1341.

59. Henson JW. Neurological complications of malignant melanoma and other cutaneous  malignancies. In Wiley R., ed. Neurological Complications of Cancer. New York: Marcel Dekker, 1995.

60. Alderson LM, Henson JW. Neurological complications of breast cancer. In Samuels M., ed. Office Practice of Neurology, 1996. New York: Churchill Livingstone.

61. Henson JW. Coupling JC virus transcription and replication. J NeuroVirology 1996;2:57-59.

62. Henson JW. Promoters for the expression of gene products in neurons and glia. In Chiocca EA, Breakefield XO, eds. Gene Transfer and Therapy for Neurological Diseases, 1998.

63. Cher L, Henson JW, Hochberg FH. Paraneoplastic neurological syndromes. In Vinken PJ, and Bruyn GW, ed. Handbook of Clinical Neurology Vol. 27 (71): Systemic Diseases Part III Chap 27, M.J. Aminoff and C.G. Goetz, series editors, 1998 Elsevier Science B.V.

64. Avgeropoulos N, Henson JW. Primary meningeal sarcomas. In Johnson D, et al. eds. Textbook of Uncommon Cancer 1999.

65. Henson JW. Glioblastoma, anaplastic astrocytoma, and anaplastic oligodendroglioma. A patient guide. MGH Brain Tumor Center, 1999.

66. Henson JW. A guide to chemotherapy for patients with high-grade gliomas. MGH Brain Tumor Center, 1999.

67. Henson JW, Louis DN. Edward Pierson Richardson Jr., M.D. and the discovery of PML. J Neurovirol 1999:5;325-326.

68. Henson JW. Early genetic events in the formation of astrocytomas. In Curr Opin Neurol 2000;13:613-617. Henson JW, ed.

69. Sharis C, Henson JW. Neurological complications of radiation therapy. Up-to-Date. 2001.

70. Kim H-S, Henson JW, Frisque RJ. Transcription and replication in the human polyomaviruses. In Human Polyomaviruses: Molecular and Clinical Perspectives. Khalili K,  and Stoner GL, eds. 2001.

71. Henson JW. Spinal cord gliomas. In Curr Opin Neurol 2001;14:679-682. Henson JW, ed.

72. Jeyapalan S, Henson JW. Neurologic Complications of Lung Cancer. In Wen P, Schiff D, eds., Neurological Complications of Cancer, 2002.

73. Henson JW, Batchelor TT. Intra-ocular lymphoma. In Primary Central Nervous System Lymphoma. Batchelor TT, ed. 2004.

74. Henson JW, Gonzalez RG. Imaging of nervous system tumors. In: Neurology in Clinical Practice. Bradley WG, Daroff RB, Fenichel GM, Jankvic J, eds. 2004.

75. Henson JW. Update on primary brain tumors: Imaging. American Society of Clinical Oncology. Syllabus, Educational Program. 2004. pp 116-119.

76. Henson JW, Gonzalez RG. Neuroimaging of glioma therapy. Expert Review of Neurotherapeutics. 2004; 4:665-671.

77. Henson JW, Gonzalez RG. Imaging. In: Cancer of the Nervous System. Loeffler J, and Black PM, eds. 2004.

78. Henson JW, Gaviani P, Gonzalez RG. Magnetic resonance imaging in the therapy of adult gliomas. Lancet Oncology 2005;6:167-175.

79. Korf BR, Henson JW, Stemmer-Rachimimov A. Case records of the Massachusetts General Hospital. N Engl J Med 2005;352:1800-1808.

80. Henson JW. Treatment of Glioblastoma multiforme: A new standard. Arch Neurol 2006;63:337-341.

81. Henson JW, Ackerman RA, Barker II FG. Comment on Petrik V et al. Godfrey Hounsfield and the dawn of computed tomography. Neurosurgery 2006;58:787.

82. Cole AJ, Henson JW, Roehrl MHA, Frosch MP. Case 24-2007: A 20-Year-Old Pregnant Woman with 5 Altered Mental Status. New Engl J Med 2007;357:589-600.

83. Ulmer S, Harris G, Henson JW. Neuroimaging issues in assessing response to brain tumor therapy. In Newton HB and Jolesz FA. Handbook of neuro-oncology neuro-imaging. Elsevier 2007.

84. Vossough A, Gonzalez RG, Henson JW, Schaefer PW. Brain metastasis. In Newton HB and Jolesz FA. Handbook of neuro-oncology neuro-imaging. Elsevier 2007.

85. Henson JW, Avitzur O. The online neurologist Nat Clin Pract Neurol. 2007 3:589.

86. Vossough A, Gonzalez RG, Henson JW. Imaging neurologic manifestations of oncologic disease. In Schiff D, Kesari S, and Wen PY. Cancer Neurology in Clinical Practice. Humana Press 2008.

87. Henson JW, Ulmer S, Harris GJ. Brain Tumor Imaging in Clinical Trials. AJNR 2008 29:419-424.

88. Henson JW. Neurology patients online: perceptions and reality. Nat Clin Pract Neurol 2008 4:347.

89. Pruitt A, Henson JW. Equal care for the elderly with low-grade gliomas? Neurology 2009 73:2056-2057.

90. Henson JW, Jung LK. Neurology on the Internet. In Avitzur O, Neurol Clin 2010 28:385-393.

91. Henson JW, Keogh BP. Plasticity: Teaching an old brain new tricks. Neurology 2010 74:53-55.

92. Mrugala M, and Henson JW. Neurological complications of malignant melanoma. In Newton H and Malkin M, Neurologic Complications of Systemic Cancer. Taylor and Francis, 2010

93. Grossheim L, Malkin M, Jayapalan S, Henson JW. Neurologic complications of lung cancer. In Newton H and Malkin M, Neurologic Complications of Systemic Cancer. Taylor and Francis, 2010.

94. Henson JW, Keogh B. Assessing radiographic response to bevacizumab in patients with GBM. In Chamberlain M, Controversies in Neuro-oncology 2010 1:94-99. Bentham Books.

95. Henson JW, Wulff, J. Inpatient Management of Neuro-oncology Patients. In Josephson, Freeman and Likosky, Neurohospitalist Medicine, Cambridge University Press, Cambridge, UK 2011

96. Henson JW, Gonzalez, RG. Neuroimaging. In Grisold W and Soffietti R, Neuro-oncology, Handbook of Clinical Neurology 2012 104:110-126.

97. Keogh BP, Henson JW. Clinical Manifestations and Diagnostic Imaging of Brain Tumors. In Lacy J and Baehring J. An Update on Neuro-Oncology. Hematology/Oncology Clinics of North America (submitted).

Program Director
NINDS NeuroNEXT Consortium at Swedish Neuroscience Institute
206-320-2645

SNI Communication Tools

SNI is leveraging communication tools that deliver information to patients, referring physicians and the public as a crucial part of providing care at the advancing edge of neu­rological knowledge. The goals of these tools are two-fold. One goal is to update established patients and their doctors regarding the latest developments in our programs and centers. The other is to lower the barrier for patients and physicians who are facing a new neuro­logical problem to discover tertiary subspe­cialty care.

A new SNI communication tool

Dan Rizzuto, Ph.D., director of SNI research, and John Henson, M.D., recently launched the SNI blog to complement other commu­nication efforts and to provide a communication outlet for the staff of SNI. The SNI blog offers brief notes about advances in neurological care provided in SNI’s centers, as well as news items about the institute that are of interest to our patients and referring physicians.

Blog content is more dynamic than Web content. Search engines are able to detect targeted key words within each entry, which helps direct highly relevant Web traffic to the blog. This aids in the dissemination of infor­mation to patients and physicians. Viewers also can subscribe to an e-mail notification system that will alert them to newly posted material.

Other SNI communication tools

Detection of Cerebral Microemboli by Transcranial Doppler

FROM BRAINWAVES: Since its introduction in 1982, transcranial doppler ultrasound (TCD) has evolved into a portable, multimodality, noninvasive method for real-time imaging of intracranial vasculature. The detection of cerebral microemboli is among the more remarkable capabilities of TCD. Emboli create countable signals in the ultrasound display due to the higher reflection of sound waves compared to the blood cells. Experimental models have shown a high sensitivity and specificity for detection of a variety of substrates, including thrombotic, platelet and atheromatous emboli.

Microembolic signals (MES) within the intracranial vasculature are most frequently identified in patients with large-vessel atherosclerotic disease, such as carotid stenosis. They have also been reported in intracranial arterial stenosis, arterial dissection, cardiac disease and atheroaortic plaque. Additionally, they have been seen in arteries distal to coiled aneurysms.

There is strong evidence that MES detection predicts future ipsilateral stroke risk in patients with symptomatic carotid stenosis (Markus HS, et al.; King A, et al.). A recent study of patients with asymptomatic carotid stenosis demonstrated that MES predicted subsequent ipsilateral stroke and TIA, and also ipsilateral stroke alone, and that it is helpful in selecting patients who will benefit from carotid endarterectomy.

Brain Tumor Board Launches WebEx® Remote Conferencing

The brain tumor board at Swedish/Cherry Hill successfully launched its first WebEx® conference on Monday, November 29 from a Seattle Science Foundation conference room. Dr. Namou Kim presented a case remotely from his office at First Hill, and an Ivy Center staff member attended the conference from the East Coast. The software allows providers to attend the conference remotely via desktop computer and telephone when a patient they refer is being discussed, or they can present films and pathology to the subspecialists present onsite at the conference. The program will now be rolled out to physicians throughout the Pacific Northwest. For more information or to present a case, contact John W. Henson, MD, FAAN, at john.henson@swedish.org or 206-320-2300.

Swedish Smyelin Babes Kick Into High Gear

 
The Bike MS Ride in Mount Vernon is almost here (September 11-12) and the Swedish Smyelin Babes bike team is 98 members strong and still growing! The team started out with 4 riders in 2006, and since then has grown to be the largest bike team, beating out even corporate groups like Team BP, Microsoft, Columbia Athletic Club and Point B. We are also the only bike team representing any of the MS centers in the Seattle region. Last year we raised over $84,000 to support the National Multiple Sclerosis Society, and we hope to beat that amount this year. Join Swedish Smyelin Babes or donate to this worthy cause!

Neuromodulation Symposium

The symposium "Advances in Neuromodulative Therapies: 2010 and Beyond" will be held August 27, 2010 starting at 7:15 am in the Swedish Education and Conference Center at the Cherry Hill campus.

See more information

A broad array of local and national experts will speak on current and future applications of neuromodulation in the treatment of neurological disorders.

FDA MedWatch - Lamictal (lamotrigine): Risk of Aseptic Meningitis

FDA notified healthcare professionals and patients that Lamictal (lamotrigine), a medication commonly used for seizures in children two years and older, and bipolar disorder in adults, can cause aseptic meningitis. Read more

Defining Tertiary Care for Neurological Diseases

Health care for patients with neurological diseases in the United States occurs across mul­tiple levels, ranging from primary to tertiary care and, less common­ly, quaternary care.

The World Health Organization has defined primary care as the point where first medical contact occurs, and where coordination and continu­ity of medical services is managed. Primary care focuses on a broad range of ser­vices, rather than the diagnosis and treatment of diseases of a specific organ system, and thus primary-care providers (PCPs) have varying levels of comfort in the treatment of neurologi­cal disorders.

Secondary care is provided by specialists, such as general neurologists, who focus on dis­eases affecting a specific organ system, usually upon referral by a PCP. Both primary care and secondary care are provided in an outpatient setting or a general hospital setting.

Tertiary neurological care is provid­ed by subspecialists who treat a subset of conditions that affect the nervous system. Examples include:

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Offices

Ben and Catherine Ivy Center for Advanced Brain Tumor Treatment
550 17th Avenue
Suite 540
Seattle, WA 98122
Phone: 206-320-2300
Fax: 206-320-8149
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