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A Phase 1b/2 Study of OMP-59R5 in Combination With Etoposide and Platinum Therapy in Subjects With Untreated Extensive Stage Small Cell Lung Cancer (PINNACLE)

The study consists of a Phase1b lead-in portion to determine the MTD of OMP-59R5 in combination with EP for 6 cycles followed a Phase 2,...

Howard West, MD
Swedish Cancer Institute

A Phase 1b Open-Label Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) Combined with Pembrolizumab in Subjects with Selected Hyaluronan-High Solid Tumors

This is a phase 1b study evaluating a combination of PEGPH20 and pembrolizumab for subjects with relapsed/refractory advanced or metastatic Non...

Philip Gold, MD
Swedish Cancer Institute

A Phase 3, Open-Label, Randomized, Parallel, 2-Arm, Multi-Center Study of BMN 673 Versus Physician's Choice in Germline BRCA Mutation Subjects With Locally Advanced and/or Metastatic Breast Cancer, Who Have Received No More Than 2 Prior Chemotherapy Regimens for Metastatic Disease

The purpose of this open-label, 2:1 randomized phase III trial is to compare the safety and efficacy of talazoparib (also known as BMN 673) versus...

Henry Kaplan, MD
Swedish Cancer Institute

Flight Attendants Medical Research Institute (FAMRI) – International Early Lung Cancer Action Program (IELCAP) Protocol

Purpose: To assess screening for lung cancer, chronic obstructive pulmonary disease (COPD), cardiac disease, and other diseases in never smokers...

Ralph Aye, M.D.
First Hill Campus

Early Recognition & Treatment of STEMI - Angel Medical Systems Guardian implant to detect ST shifts and other cardiac irregularities and alert subject to seek medical attention (ALERTS)

The purpose of this study is to evaluate the safety and effectiveness of the Guardian System in comparison to the standard of care in treating...

John Petersen II, MD
Cherry Hill Campus

USPELLA (IMPELLA 2.5®) DATA REGISTRY

The USpella data registry is collecting and analyzing existing patient records to develop best practice guidelines for the patients requiring...

John L. Petersen II, MD

The CALIBER Study Randomized Controlled Trial of LINX Versus Double-Dose Proton Pump Inhibitor Therapy for Reflux Disease

This study compares mechanical sphincter augmentation (LINX Reflux Management System) to double-dose proton pump inhibitors (PPIs) for the...

Brian Louie, MD
Swedish Cancer Institute

Reducing Health Disparities at End-of-Life

This project will test interactive, web-based training materials designed for health care providers to learn or improve cross-cultural...

Ardith Doorenbos, PhD, RN

JCV Antibody Program in patients with Relapsing MS and who are Receiving or Considering Treatment with Tysabri

Multiple Sclerosis (MS) patients taking Tysabri have an increased risk of developing Progressive Multifocal Leukoencephalopathy (PML), a type of...

Peiqing Qian, MD
Cherry Hill Campus

I-SPY 2 Trial (Investigation of Serial Studies to Predict Your Therapeutic Response with Imaging And moLecular Analysis 2)

The purpose of this study is to further advance the ability to practice personalized medicine by learning which new drug agents are most effective...

Erin Ellis, M.D. and Henry Kaplan, M.D.
Swedish Cancer Institute
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