PRE-CONCEPTIONAL COHORT STUDY OF METABOLIC ABNORMALITIES IN RELATION TO INCIDENT PREECLAMPSIA AND PR

PRE-CONCEPTIONAL COHORT STUDY OF METABOLIC ABNORMALITIES IN RELATION TO INCIDENT PREECLAMPSIA AND PRETERM DELIVERY IN CHINA

Type of Study
Perinatal Studies - Perinatal Research
Location
First Hill Campus
Short Description

This project is a pre-conceptional prospective cohort study of 5,000 nulliparous women enrolled prior to conception and followed throughout pregnancy and until 6 weeks postpartum. Nulliparous women residing in two cities/counties in northern China (Hebei Province) and two cities/counties in southern China (Zhejiang Province) will be enrolled in this study. The main objectives of the study are to 1) determine the extent to which pre-conceptional and early pregnancy markers of maternal endocrinological, immunological, vascular, and renal function (lipids, lipoproteins, C-reactive protein, soluble vascular cell adhesion molecule-1, cystatin C, and oxidized low density lipoprotein) at baseline are associated with subsequent risk of preeclampsia; and 2) determine the extent to which markers of maternal thyroid hormone status (and especially degrees of maternal hypothyroxinemia at baseline and in early pregnancy) are related to the risk of preterm delivery.

Status
Open to enrollment of women in China ONLY
Principal Investigator
Michelle Williams, ScD
Eligibility Notes

  • Married woman
  • Nulliparous woman
  • Between ages 20 and 40 years
  • Attend pre-marital health examination clinics in participating healthcare facility
Contact Name
Chun-fang Qiu, MD; Alternate Contact: Ihunnaya Frederick, PhD
Phone
(206) 386-3332
Email
chun-fang.qiu@swedish.org
Alternate Email
ihunnaya.frederick@swedish.org