5158W-11 Intravenous acetaminophen for craniotomy patients

Intravenous acetaminophen for craniotomy patients

Type of Study
Neuroscience - Craniotomy /Interventional
Short Description

Explore if using intravenous acetaminophen just before and just after a craniotomy can reduce the amount of opioids a patient needs, which results in less nausea and vomiting.

Status
Open
Principal Investigator
Arthur M. Lam, M.D.
Eligibility Notes

Inclusion:

  • Male or female patients 18 years of age or older.
  • Undergoing an open, elective intracranial procedure for tumor resection aneurysm clipping, or revascularization.
  • Have an ASA (American Society of Anesthesiologists) status of 1, 2, 3, or 4.

Exclusion:

  • Have a condition or disease that, in the opinion of the Principal Investigator, would compromise the patient's welfare or safety
  • Current daily chronic opioid use in excess of 40-mg morphine equivalents or any tramadol use.
  • Treated with MAO inhibitors 10 days before surgery.
  • Treated with any amount of acetaminophen within 8 hours of anesthesia.
  • Have known hypersensitivity to acetaminophen or the inactive ingredients of IV acetaminophen or anycontraindication per manufacturer's guidelines.
  • Preganacy
  • Impaired liver function.
  • Participation in an interventional clinical study within 30 days of enrollment.
  • Known or suspected history of drug or alcohol abuse.
  • Surgery for resection of acoustic neuroma.
  • Surgery using a transphenoidal approach for tumor resection.
Contact Name
Becky Wood
Phone
206-320-7115
Alternate Phone
206320-3542
Email
becky.wood@swedish.org