Swedish News Blog

What you should know about Multiple Sclerosis (MS)

Bobbie (Barbara) J. Severson, ARNP

Bobbie (Barbara) J. Severson, ARNP
ARNP, Swedish Multiple Sclerosis Center

You hear the diagnosis multiple sclerosis (MS) and your world stops. You don’t know what to think, who to tell, or what to do about your future.

In this video, four people living with MS tell their stories:

But even if you aren’t diagnosed with MS, here are some things you should know:

Sexual Dysfunction in Multiple Sclerosis

Bobbie (Barbara) J. Severson, ARNP

Bobbie (Barbara) J. Severson, ARNP
ARNP, Swedish Multiple Sclerosis Center

Although Inga is quite able bodied, she is having sexual problems. Sexual dysfunction, which may occur early or late in the course of MS, does not always correlate to the degree of physical disability. Often it is under-recognized and goes untreated. It is present in up to 90 percent of men and in nearly as many women. In women, the most common problems are low libido and altered genital sensation. For men, the major problem is erectile dysfunction.

Sexual dysfunction can be a direct result of demyelination in the central nervous system. Secondary changes are related to poor bladder control or muscle weakness, and psychological, social or cultural issues that interfere with sexual feelings or responses. Examples of the latter include alterations in body image and low self esteem.

Regardless of the cause, sexual dysfunction can adversely affect quality of life and contribute to additional problems. 

Pharmacologic Treatment of Nystagmus in Multiple Sclerosis

Eugene F. May

At least half of all people with multiple sclerosis (MS) are expected to have nystagmus at some point during the course of their illness. Nystagmus results from demyelination that involves the brainstem or cerebellar eye movement pathways. While it may be asymptomatic, it often causes blurred vision or oscillopsia. The extent of the visual disturbance is directly related to the velocity of the slow phase of the nystagmus.

In MS patients with chronic nystagmus, the most common form is an acquired pendular nystagmus (APN), which is almost always accompanied by optic atrophy, and often by internuclear ophthalmoplegia (INO).

Numerous treatment trials have demonstrated the efficacy of pharmacologic treatment of chronic symptomatic nystagmus. Treatment should be considered in individuals in whom blurred vision or oscillopsia is severe enough to warrant the potential risk of medication side effects. As a general rule, drugs used to treat nystagmus are titrated slowly upwards from a low dose to either efficacy or tolerance.

The two most effective medications for APN in MS are....

Emerging therapies in multiple sclerosis

Lily K. Jung Henson, MD

Multiple sclerosis is unique among neurological diseases in that there are currently eight treatments for this one condition that have received approval by the U.S. Food and Drug Administration (FDA). Five of these drugs require subcutaneous or intramuscular injection, two are administered intravenously, and fingolimod, the newest agent on the block, is given orally. None are considered curative, but these disease-modifying therapies (DMT) have led to a reduction in relapse rates and the progression of disability.

Despite this progress, each of the drugs comes with side effects, including flu-like symptoms with the interferons, lipoatrophy with glatiramer, progressive multifocal leukodystrophy (PML) with natalizumab, and congestive heart failure or leukemia with mitoxantrone. As the first oral agent for MS, fingolimod created great expectations prior to FDA approval. Its popularity, however, has been surprisingly limited, presumably due to the potential for unknown long-term risks. The occur rence of PML with natalizumab demonstrated to MS neurologists and patients the potential risks associated with new drugs.

Additional DMTs in the pipeline may increase MS-management effectiveness in coming years, although safety will continue to be a major consideration in the use of these drugs. For instance, oral cladribine was on the verge of FDA approval in early March when the agency referred the drug back for more safety studies. This drug is already used in intravenous form for the management of hairy cell leukemia, but it is being studied for use with remitting relapsing MS because of its apoptotic effects on lymphocytes. If cladribine is ultimately approved for use, the risk of infection and neoplasms may limit its use.

Other oral agents being studied include:

Multiple Sclerosis Center 2nd Annual Art Show 2011

Bobbie (Barbara) J. Severson, ARNP

Bobbie (Barbara) J. Severson, ARNP
ARNP, Swedish Multiple Sclerosis Center

The Multiple Sclerosis Center at Swedish Neuroscience Institute is hosting its Second Annual Multiple Sclerosis Center Art Show at the Bellevue Arts Museum on Saturday and Sunday, June 18 & 19, 2011 from 11:00am to 5:00pm. There will be an ‘Artist Only Meet ‘n’ Greet, Sunday June 19th from 3pm – 5pm

Entry Criteria:

Multiple Sclerosis Center Continues to Grow

James D. Bowen, MD

The Multiple Sclerosis Center continues to grow. We have added an additional MS nurse, Reiko Aramaki, RN. Reiko joined us from the Evergreen MS Center. She is certified by the International Order of MS Nurses and will expand our ability to respond to patient’s needs.

Outreach programs also continue. Dr. Bowen was recently interviewed by Kathi Goertzen from KOMO TV4 regarding CCSVI. This interview can be seen at http://www.komonews.com/home/video/106166123.html.

Also, Chaz Gilbert, a patient care coordinator won the Seattle Verizon Urban Challenge on 10/30/10, racing through 12 checkpoints in their city using only clues, their feet and public transit.

Exciting Advances in Multiple Sclerosis from ECTRIMS

Karen Pabillon

There is exciting news from last week’s 26th Congress of the European Committee for the Treatment and Research in Multiple Sclerosis (ECTRIMS) in Gothenburg, Sweden.

ALEMTUZUMAB. 5-year data from a Phase II extension study for alemtuzumab, an intravenously administered monoclonal antibody, showed that the drug:

  • reduced annualized rate of relapse to 0.14 compared with 0.28 for interferon
  • reduced the risk for sustained accumulation of disability in remitting relapsing multiple sclerosis by 87% compared to 62% with interferon.

This is a remarkable agent with excellent activity in MS. Adverse events included immune thrombocytopenic purpura, thyroiditis and anti-glomerular basement membrane disease.

TERIFLUNOMIDE. A Phase III trial of oral teriflunomide in remitting relapsing MS showed:

  • a 31% reduction in relapse rate and increased time to first relapse compared with placebo
  • reduced the risk of sustained disability progression by 29.8%.

Side effects were mild and included diarrhea, nausea, liver function abnormalities and hair loss.

Alemtuzumab and teriflunomide are currently in Phase III clinical trials at SNI.

SNI PRESENTATIONS:

  • Dr. Jim Bowen presented a poster about ongoing demyelination and neurodegeneration in a patient who had undergone autologous stem cell transplantation.
  • Drs. Jung Henson and Mayadev reviewed the beneficial effects of exercise on functional and quality of life outcomes from SNI’s MS wellness program
Results 71-77 of 78

More information about the Swedish newsroom

Explore the rest of the Swedish blog

Swedish has a social media policy

See who is blogging at Swedish

   Keep up with Swedish:

    Check out the Swedish blog

Find a Physician

              Subscribe to
             HealthWatch